Pharmacokinetics | Drug Distribution

You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:

Ninja Nerds!
In this lecture Professor Zach Murphy will be presenting on Pharmacokinetics, specifically discussing Drug Distribution. We hope you enjoy this lecture and be sure to support us below!

Table of Contents:
0:00 Lab
0:07 Drug Distribution Introduction
0:54 Factors Affecting Distribution
8:00 Protein Binding
17:05 Volume of Distribution
25:25 Drug Distribution Practice Problems
29:18 Comment, Like, SUBSCRIBE!

Pharmacology Source:
Whalen, Karen. Lippincott Illustrated Reviews: Pharmacology (Lippincott Illustrated Reviews Series). Wolters Kluwer Health.

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[hesten]

I bet that I am not the only pharmacy student out there who is super grateful for these videos❤😂 Thank you so much!!❤

[colemanhelm]

These pharmacokinetics videos are coming out literally at the perfect time. Looking forward to metabolism and elimination.

[ahutamorris]

Now it's 3 years following you and I have gained a lot from you. Watching from Kenya (Nairobi).

[emaderecichei]

I had been struggling to understand the protein binding drug until I saw your video. You are a very good teacher! Thank you and God bless you!

[mikegox]

All your videos are very informative. You are the only person born in this world to help medical students, doctors, and even professors too. CONGRATULATIONS!!

[alluparantha]

You were put on this earth to teach. Honestly, thank you so much.

[brolistic]

I'm studying occupational, safety and health. One of my required classes is toxicology, and this video is a lifesaver. God bless and Thank you for your contributions sir!

[mohammedisak]

Masha Allah I'm from Somalia🇸🇴 We proud of You Me and My friends For your Hardworking Thank you For Your Helping us With Out you I'm sure that i can't know something About Medicine.
Thank you.

[hussainahmad]

It was my desire to learn general pharmacology from u so now I m happy after seeing these types of lectures love from Pakistan kpk khyber❤❤

[jadec]

This needs to be added to the pharmacology playlist

[lindseyrhodes]

just started pharm in pa school... perfect timing with these videos getting released!

[nouraraji]

I am a med1 student and its the first video of yours that I watch, definitely won't be the last .

[poojajollin]

Hi .. I have been preparing for my Pharmacy exam and all the points mentioned here is very important to remember and is also easy to understand. I have been looking at diff other videos as well, but nothing as clear and well explained as this one. Thank you very much!

[mahmad]

MashAllah, brother Zachary. May Allah bless you more.

[LondonBurg]

An important concept about VoD to note is the definition of VoD: The APPARENT volume of distribution is the theoretical volume of fluid into which the total drug administered would have to be diluted to produce the concentration in plasma. It is not the actual volume that the drug is distributed within the body because that would limit the volume to apprx 42L in the average human. This is why we get numbers in the thousands.
(Edit to include ex.): If you needed a drug to be at 100mg/L in the blood and you know the VoD of the drug is 200L you would have to give 100mg/L x 200L = 20, 000mg or 20g of that drug to achieve the desired concentration in the plasma Assuming no first pass metabolism).
please correct me if I am wrong. Happy studies everyone.

[MarjohryEmmanuel]

Pharmacy students, let's gather here😍. Thank you so much, you're an angel!

[kryptonite]

i am 1st year medical student and i am super grateful for your videos. It's helping me a lot to understand my course.

[elijahkurien]

At the end of the unit could you do a video on a case study on a drug like Tylenol or Aspirin and how its pharmacokinetics affects its distribution?

[RobinJones-cz]

Thank you so much for putting practice questions at the end!!

[julianagarcia]

You are simply awesome!!! I want to understand these concepts very well for my USMLE exam. Thank you for breaking down tough concepts into basic, very easy to follow chunks.