What Is Colloidal Silicon Dioxide Excipient? Properties | Uses | Safety

@pharmacental #excipients #pharmaceuticalformulation

Colloidal silicon dioxide is amorphous silica prepared synthetically by the vapor-phase hydrolysis of a silicon compound. Although it has the chemical formula SiO2 it is distinct from other types of silica, such as amorphous or crystalline silica that exist naturally or other silicas obtained synthetically such as silica gel or precipitated silica.

The grade used in pharmaceuticals is supplied as a white or almost white, light, fluffy, and extremely fine powder. It serves as an anticaking agent; emulsion stabilizer; glidant; suspending agent; thermal stabilizer; viscosity-increasing agent; desiccant, and solubility-enhancer.

*Sources/References*
Influence of mixing time, particle size and colloidal silica on the surface coverage and lubrication of magnesium stearate. Johansson, M. E., Nicklasson, M. Rubenstein, M. H. Ed.,Pharmaceutical Technology, Volume I, John Wiley & Sons, England, 1987

Jonat, S., Hasenzahl, S., Gray, A., Schmidt, P. C. Influence of compacted hydrophobic and hydrophilic colloidal silicon dioxide on tableting properties of pharmaceutical excipients. Drug Development and Industrial Pharmacy 31 (2005) 687-696.

Dal Zotto, M., Realdon, N., Ragazzi, E., Dalla Fini, G., Farmaco 46 (5) (1991) 699-711. Effects of two different kinds of silicon dioxide on release of drugs from suppositories: benzydamine hydrochloride.

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