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Learn how to Encapsulate Hydrophilic API in PLGA
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This webinar hosted by Dr. Pavel Abdulkin uses Dolomite systems to explore the most suitable microfluidic methods for encapsulation of the hydrophilic active pharmaceutical ingredient (API) in PLGA particles. The focus of the session was to explore difficulties of standard methodologies and how you may overcome it with microfluidic technology to achieve encapsulation efficiencies of almost 100%.
1) Introduction: 0:00 - 2:04
2) Microfluidic technology and how it works: 2:04 - 4:44
3) Droplet / particle production methods: 4:44 - 7:25
4) Dolomite systems including scale-up with Telos: 7:25 - 8:46
5) PLGA microparticles - particle formation process & solvent extraction process: 8:46 - 12:20
6) PLGA nanoparticles - particle formation process: 12:20 - 13:42
7) Methodology 1: Multiple emulsions - system set-up & results: 13:42 - 17:35
8) Methodology 2: Direct powder encapsulation - system set-up & results: 17:35 - 20:32
9) Methodology 3: PLGA nanoparticle production - system set-up & results: 20:32 - 23:10
10) Emulsion stabilizers: 23:10 - 24:32
11) Conclusions, system overview & additional information: 24:32 - 28:08
1) Introduction: 0:00 - 2:04
2) Microfluidic technology and how it works: 2:04 - 4:44
3) Droplet / particle production methods: 4:44 - 7:25
4) Dolomite systems including scale-up with Telos: 7:25 - 8:46
5) PLGA microparticles - particle formation process & solvent extraction process: 8:46 - 12:20
6) PLGA nanoparticles - particle formation process: 12:20 - 13:42
7) Methodology 1: Multiple emulsions - system set-up & results: 13:42 - 17:35
8) Methodology 2: Direct powder encapsulation - system set-up & results: 17:35 - 20:32
9) Methodology 3: PLGA nanoparticle production - system set-up & results: 20:32 - 23:10
10) Emulsion stabilizers: 23:10 - 24:32
11) Conclusions, system overview & additional information: 24:32 - 28:08
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