Sickle cell anemia

Sickle cell disease
autosomal recessive inheritance
partially acceptable missense point mutation
polymerization of deoxy HbS causes sickle shape RBCs
glutamate is replaced by valine at 6th position of beta chain

C/F
pain
hemolytic anemia
jaundice
repeated infections

Lab diagnosis
Sickling test
Hb electrophoresis
HPLC

treatment

Hydroxyurea
blood transfusion
stem cell therapy
gene therapy

[nitinkhasdeo]

Sir we only depend on your lecture

my whole batch at Hostel watches you in exam time in one screen
these videos are like sanjeevani for us

[strugglingdoctor]

First yr भी आपके videos देख पास हुआ था.... Final yr में भी आपके वीडियो का help मिल रहा है.... Thank you so much sir 🙏🙏🙏🙏🙏✨

[raju]

Sir ur really super...!! I don't read my biochem textbook at all I just see ur videos and write the exam.. and I think it is much more enough..!! 😊😊Keep going sir..

[drpappulohot]

बहुत बहतरीन cme व्याख्यान के लिए शुभकामनाएँ ।

[mayanksharma]

Sir you r living legend in this teaching line.

[i_mermaid]

Sir ...please teach more diseases of pathophysiology like this...
Thanks a lot😊

[morphineshot]

Thank u sir u made the biochemistry easy for me and this video is also very helpful.thank u so much

[aparanasaini]

Well explained sir . This is really helpful .thnq so much🤗

[dhruvsharma]

Thank you sir for making it this easy to understand ☺️.

[abdullahshahqureshi]

Plz sir put lecture on hemoglobinopathies

[rajkothari]

Sir, could you please make a video on malaria resistance in heterozygote sickle cell disese trait ?

[mbbswithadarshpanchal]

Sir plz lecture on hemoglobin structure and oxygen dislocation curve plzz sir .

[mms_mslaw]

Sir can u post video about thalassemia?

[morphineshot]

I have a question
What come first DNA or enzyme helicase and gyrase .