Immune Checkpoint Blockade in Cancer Therapy

[aadilhussain]

(And day before yesterday i.e Monday, 1st October) Dr Allison jointly with Dr Honjo, has been awarded the 2018 Nobel prize in physiology for their discovery of cancer therapy by inhibition of negative immune regulation.❤

[leeakiyama]

a man deserves respect of entire humanity

[data]

It was a real pleasure being at MD Anderson a few years back listening to his lecture.

[joelheadlover]

Nobel prize for cancer therapy for the first time! Congratulations!!

[sabrinastanley]

Why immunotherapy is thought to be a superior treatment for cancer? (Hint: 3 reasons)
 
 Specificity, memory, adaptability
 
2. What is the normal role of CTLA4 in the immune activation signaling?
 
 
3. How does the antibody that binds to CTLA4 induce tumor rejection?
 
 
 
4. Look at the graph at 10:14. Briefly discuss the significance of this data; what does this data tell you?

 
 
5. is the first anti-CTLA4 human monoclonal antibody which generates anti-cancer response in many patients with different tumor types. This drug has since been used as the ‘standard care’ for cancer.
 
6. Briefly discuss how Nivolumab work.
 
 
 
 
7. Why would combining anti-CTLA4 and anti-PD1 result in greater tumor rejection and better cancer remission?
 
 
 
8. Look at the ‘survival curve’ at 36:52. Briefly explain the main point of this data.

 
 
 
 
 
 
9. How is this cancer immunotherapy (discussed in this video) different than the CAR-T cell cancer immunotherapy discussed in the class?
 
 
 
10. After listening to the whole lecture, discuss your thought on the future outlook of cancer immunotherapy and how is it relevant to your future career. 1 – 2 paragraph(s).

[biologyworkout]

*god bless you Alison you are going to do something never happened for humanity*

[xuedanhe]

Oh my god, this is Allison, the father of Ipilimumab

[bpath]

Thank you, there is light at the end of the tunnel, the 10 year survival slide is impressive !

[shinmancheung]

Allison has just won the Nobel Prize in Physiology or Medicine 2018 with Tasuku Honjo.

[DonaldWilliamsRox]

Whether though CD4+/CD8+ or macrophage cells taking the "breaks" off via aCTLA-4/aPDL-1 or even via aVISTA it truly looks like you can "raise the tails" to a much more parallel trajectory with the X-axis which is truly an exquisite paradigm shift for those affected by oncologic pathology. Bravo to you and your team!

[arnsteinholm]

If the amount of Akkermansia gut bacterias has a crucial effect on why some checkpoint immunotherapies has different responses on different patients …… How can I improve the population of my Akkermansia gut bacterias?
Is it correct that unlike Lactobacillus or Bifidobacteria or other species you can “take” in a capsule, Akkermansia has to be fed by pomegranate juice and/ or cranberry juice weeks prior to these kind of therapies ?

[auroshikhamohanta]

It is a grat discovery sir. This will save the lives of billions. Bt there is one question. Isn't this removal of brake on CTLA 4 and PD1 can cause autoimmune disease, as the brakes are removed??? How the breake removal will be localised???

[leilihadad]

I want to know expression kinetic PD-1 and Tim-3, may you help me?

[genesqaured]

Allison， found CTLA-4 as brake of T Cell

[rathodnv]

My father suffering non hodgkins lymphoma pls advice