Long Term Side Effects of PPI Use Pt. 1

Are you currently taking a PPI and consider stopping it because of the potential long term side effects from using it? Did a doctor prescribe a PPI to you, but are hestiant to start because you heard it has long term side effects? If so, this video is for you!

There are four main concerns of long term use of PPIs. But that would be a lot to discuss- so lets talk in this video on the malabsorption of vitamins and minerals and the potential increased risk of infections.

What are the claims made about the malabsorption of vitamins and minerals when you take PPIs for along time? If stomach acid plays a role in absorbing minerals and vitamins then wouldm't decreasing that acid lead to malabsorption? How does our diet contribute to absorption of vitamins and minerals? What if your vitamin and mineral levels do drop slightly, is that bad? Does lower calcium absorption lead to osteoparosis or bad bone health?

Isn't our stomach supposed to be very acidic? Doesn't this acid prevent against GI infections? Is there an increased risk of infections with long term use of PPIs? And if so, what is the magnitude of the risk? What else does the body use to ward off infections?

When should patients try to get off of PPIs? What infections and conditions increase that risk when combined with long term PPI use?

Why do we make so much stomach acid if it isn't really needed? Does our diet require all the stomach acid we produce?

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DISCLAIMER: While I am a Gastroenterologist, I am not acting as your Gastroenterologist. The information provided on this channel is intended to be general educational content and not directed towards any one individual. If you believe you have a medical condition that deserves attention please seek care from your healthcare provider. If you are experiencing a life threatening emergency, call 911.

[benjamesv]

Thanks doc. The internet made me paranoid about PPI, you've cleared it up for me. thanks

[Zilero]

As someone who was prescribed this for chest pain, it’s totally eliminated it and improved my life in a big way. Unfortunately, there’s a lot of scary articles if you Google the long term effects, but this timely video really made me feel better about not discontinuing it after just a couple of months. Thanks Mark 🙏🏼

[kerikrogel]

After having a little reflux during pregnancy (I hadn't known that pregnancy reflux can go away on its own after pregnancy) my doctor immediately put me on max dosage PPI's, didn't tell me there would be any consequences, and didn't inform me that she planned to have me take them for the rest of my life. When my blood iron dropped to 2 micrograms, I asked if I could get off the PPI's. She dismissed my concerns, but I can't go to another doctor, there is only one doctor who can prescribe medication for a two hour drive from my home. I've been on PPI's for 27 years now, I'm going to switch to a carnivore diet and hope for the best.

[Jahnavasundari]

My surgeon agrees that it’s “bad science” and media hype that scare people into thinking PPIs will be the downfall of western civilization 😅
I need to be on PPIs basically forever bc I needed a surgery to permanently open my LES. (So there’s nothing keeping the acid in my stomach anymore.) I was really freaked out about the side effects, so I appreciate this.

[thathippielookingchick]

After I started taking a PPI, my digestive pain and virtually all of my anxiety went away. My life improved so dramatically that I'm scared to go off it, but I see so many articles about the dangers of taking them long-term. Is there a way to know if I'm suffering long-term damage? How can I tell if I'm not absorbing enough nutrients? I may try to wean myself off eventually, but it sure is nice to live pain-free and anxiety-free.

[JIMKATSANIDIS]

Great information! The short use of PPI may have minor side effects like headache, dizziness, rash, diarrhea, nausea, flatulence and constipation. Long-term usage may lead to chronic kidney disease, bone fractures, dementia, pneumonia, vitamin B12 deficiency. Thanks for the very useful and helpful video Dr. Mark!❤👍

[nasko]

Unfortunately I've had GERD for the majority of my life (I'm 30, had it since I was 12) and it appears its a mechanical issue with a hiatal hernia. I've lost weight, have eaten as healthy as possible, I'm not drinking alcohol at all and yet I have horriffic episodes of reflux followed by throat pain. Just taking PPIs for a few days has improved my quality of life MASSIVELY, as I can now get full 8 hours of sleep without waking up with a throat full of acid. I'm fearful that the only permanent solution to my problem might be a hernia surgery which is bost costly and any surgery has risks associated with it but so does taking PPIs for life.

[likethepear]

I’m terrified. I have crohns and am on Remicade so I’m kind of used to gastric issues but lately acid reflux has been really getting to me. Last night after sleeping for an hour I woke up choking on vomit.Even when I stop eating 6 hours before bed and don’t eat anything spicy or fatty this still happens. The acid/vomit was on my sheets and I was gasping for air. This has happened a few times. I’m terrified I’ll end up with pneumonia from it. my gastroenterologist put me on Aciphex last year for 4 months and it worked great. I could eat anything anywhere anytime but I had to. Stop taking it after four months. I don’t understand why they make these great drugs that you can only take for a short period. It was like I had a normal life and now I don’t know what to do. I’m so depressed, afraid to go to bed. I can’t sleep on a wedge because of neck problems. I don’t know what to do anymore except just stop eating all food .

[shirleysparks]

I was recently diagnosed with gerd / silent reflux . Through an EGD. I am on a ppi now to help heal it. I also had h pylori did the protocol of antibiotics, and that has cleared . But what I don't understand is how do I know this is healing ? I never had any symptoms. It was only found because we were trying to find a cause for another issue.

[KittyKat-jvnq]

I keep reading from many sources that taking a hydrochloride acid supplement will help with digestion. Is there any situation where this will help? Im a long time ppi user but have bloating and gas.

[TaembedzwaMajaya]

I have terrible GERD and I have been on Dexilant for close to 2yrs now. But i also have chronic urticaria and connective tissue disorder. I am on high dose of Xolair and I also take hydroxychloroquine. But lately my GERD has been extremely painful and don't know how to manage it and i am a young mum seeking for a better quality of life

[RealTraderScalper]

Is it true that long term ppi use are directly linked to cause IBD

[blueberry]

Is there any exercises that you recommend for acid reflux? I feel bitterness in my mouth and throat every single day for a long time. Can’t wedge my bed because of neck pain. Keep drinking baking soda and water!!! And keep burping. I’m very worried about my esophagus 😢😢

[ilanaryz]

I am so glad I found your channel. My husband was recently diagnosed with EOE, and you provide so much of great information. He is getting ready to start elimination diet and he needs to take PPI at the same time. He doesn't have any symptoms, so it was only endoscopy that confirmed the diagnosis. I do however have a question if I may. How about interaction with thyroid medication like Levoxyl? Both, PPI and Levoxyl need to be taken on an empty stomach, but can't be taken at the same time. And there is also some information that PPI may affect absorption and levels of Levoxyl may need to be adjusted. Would like to hear your thoughts, or maybe even a video about medication interactions. Thank you.

[nwz]

I have taken PPI for 12 days.
I have felt tired, brain fog, joint pain. I decided not to take them. my symptom is only reflux, and this is not worth it.
But I need to know. Is the PPI inhibiting cognition permanent damage? I'm scared. and alone. please let me know.

[BA-bevm]

Great video. Lansoprazole is the only thing that seems to help my acid reflux from a hiatal hernia, i am only young and have already been on the PPI for years, i am worried that i will be on them forever and it will have negative consequences on my health.

[KirstinRN]

Have you heard of gastric polyps related to long term ppi use? I recently had an endoscopy & colonoscopy due to abdominal bloating, nausea, change in bowel habits (w/ history of colon polyps) & because of my history of GERD. They found that I have several gastric polyps (over 30, some very large at 2cm) & want me to stop taking a ppi. I had no idea that was a long term complication/risk factor. However, I was told they should shrink & go away when I stop the ppi. Have you seen that in practice before? I’ve been on a ppi for many years.

[Outlander]

What do you suggest for hiatal hernia reflux?

[chadgross]

Hello Dr. Cooper,

Thank you for the excellent video. I have a question for you. I have been reading that acid reflux and heartburn are most often the result of low stomach acid, not too much stomach acid. So, if this is true, isn't treating AR and heartburn with PPIs counterproductive? Please know that my question is sincere and I am not trying to contradict anything you have said here. I am seeking understanding.

Thank you again for helpful video. It was a nice change of pace from the typical "PPIs are the devil" videos!

[Lovemyfamily]

Please do part 2. My medication for cronic pain causes LPR which is acid reflux in the throat and air ways that responds to 40mg of omeprozole. When I am off the medication LPR goes away and no need for PPI. However I am in so much pain can’t do anything and no other medication has been able to help my cronic pain. I want to go back to my original medication because it works even though it causes LPR and I will need to be on a PPI long term. But everything online about PPI scares me. Please advise Dr.