Mitochondria: the cell's powerhouse

In this animation, Professor Rob Lue introduces the mitochondria, the powerhouses of the cell.



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[abrahamtellezv]

It's incredible how many years of knowledge piled upon knowledge are condensed into just this 5 minutes.

[BradenB]

The mitochondria is the powerhouse of the cell

[speedstriker]

I knew that the MITOCHONDRIA IS THE POWERHOUSE OF THE CELL, but I didn't know they were literally tiny biomechanical power plants. This is amazing!

[abenassini]

Beutiful and elegant animations. I’m a physician and I’ve never seen the process of cyclic AMP presented in such a graphical way.

[Foxiepawstotti]

Apart from the fact the whole mitochondrial set up is so amazingly complex, this makes it look really beautiful too.

[stefanofalone]

Great video, however at 2:38: "Electron transport in complexes II, III and IV is coupled to pumping of protons..."
Actually, it's I, III and IV.

[Proversiongamer]

Never thought I would spot a mistake in a HarvardX Video, but the ATP Synthase subunit is called Fo not F0 (zero). The letter o stands for Oligomycin.

[aspektx]

Seeing things like this makes me realize how inconceivable the stretches of time are for things like the mitochondria to develop.

All the failures, the variations that partially worked, and the diversity that must have occurred on the path that led to something so small and so significant.

[parulshukla]

Harvardx....I m a practising pediatrician from India. Such animation weren't available in studied in the medical school many years ago


Seeing this animated medical teaching makes me feel my medical school revisited

A back to school experience

[AMeDAS.Hunter]

2:29　Water molecules are synthesized on the matrix side.But in this animation, molecules of water are synthesized on the intermembrane space side.

[OGMann]

Mitochondrial dysfunctions are implicated in a significant number of pathologies. It's a fascinating field of study. The various hypotheses of the organelles origin are equally interesting.

[averylawton]

It has been a few years but here I am again to marvel. I adore these videos so much. I have shown all my children and friends and even random people I have interacted with. Thank you all so much for making this.

[deanroddey]

As a software developer, I now know what I sound like to non-software developers.

[higherresolution]

At MINUTE 2:45 a mistake is made. Complex II does not pump protons into the intermembrane space. Complex I, III and IV do that job of creating the proton motive force that drives the 8-proton rotation cycle of the ATP Synthase turbine.

[-AnyWho]

they already have a video game based on this (still in early stages of development) ... soon little kids will understand this better than we do

[convergence]

Спасибо большое за визуализацию работы митохондрий, что в свою очередь очень помогает осознать сам цикла Крабса и запуск электротранспортной цепи.

[GlynWilliams]

Amazing.
I want to understand what I saw

[fierrots]

It is not F0 (zero) but FO (oligomycin-sensitive)

[myersred]

If it makes energy, it is not the POWER house, it is like the refinery, the source of FUEL production. I don't look at an oil refinery and go, "Look at the power house!" I wish there were more videos about how ATP is used rather than how it is created.

[joshuawalker]

Summary
This video explains the structure and function of mitochondria, the organelles responsible for producing ATP in eukaryotic cells. It details the process of protein transport, cellular respiration, electron transport, and ATP synthesis within the mitochondria.

Highlights
Mitochondria are organelles responsible for producing ATP in eukaryotic cells. 💡
Most mitochondrial proteins are transported into mitochondria through specialized protein translocator complexes. 💡
Cellular respiration, which involves the oxidation of carbon fuel molecules and production of reduced electron carriers, occurs in the protein-rich matrix. 💡
ATP synthesis is driven by the proton motive force, which is created by the pumping of protons across the inner mitochondrial membrane. 💡
Mitochondria can undergo dynamic changes in shape and distribution, and perturbations in their behavior are associated with programmed cell death. 💡