Directionality of Nuclear Transport | Cell Bio | Video Textbooks - Preview

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The directionality of transport is maintained by a small monomeric protein Ran, complexed with GTP. Ran-GTP helps nuclear export receptors or exportins to load the cargo, and binds to the import receptor or importin to unload the cargo in the nucleus.
Within the nucleus, Ran is regulated by the chromatin-bound Ran-Guanine nucleotide exchange factor or Ran-GEF, which converts RanGDP to RanGTP.