New cancer theory! (#161)

A recent paper that introduced a new cancer theory based on faulty mitochondria function in cancer stem cells. We go through this introductory paper to see why the authors propose renewed attention to cancer development and treatment based on mitochondria function, especially for metastatic cancers.

Originally published on Patreon on December 21, 2024

What we cover:
*Different cancer origins theories
*Why the predominant somatic mutation theory does not work
*Why the mitochondria function theory makes sense
*Review of the mitochondria stem cell connection theory

Location: Sunshine Mountain, Alberta

Described content:

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[LTPottenger]

Definitely on the right track. Fasting and a low carb diet are the best way to ensure your mitochondria stay healthy! The many benefits of occasional extended fasting and lowering dietary carbs:
Your body recycles up to 1/3 of all immune cells in a 72h fast, rejuvenating your immune system. This helps with autoimmune disease, cancers and cytokine storm.

Fasting stimulates phagocytosis, the ingestion of proteins, pathogens and plaques by macrophages and other immune bodies. This will remove spikes quicker, whether natural or unnatural in origin!

Clots and plaques are removed over time due to accelerated phagocytosis.

When insulin is high, vit D stays locked in the blood cells but fasting quickly lowers it. Vitamin D plasma levels are increased as fasting improves metabolic health, and D in turn increases autophagy.

Your brain prefers to burn ketones at a rate of around 2.5 to 1 when equally available to glucose. Except for brief periods of very intense exercise, your body mainly burns free fatty acids.

Fasting and low carb help with POTS, which is driven by high insulin and blood sugar.

Fibrosis aka scarring is reversed over time, including in the heart, lungs and clots.

Clotting and fibrin are inhibited, stopping any 'unusual' clots.

Fasting quickly lowers blood pressure levels.

The hunger hormone ghrelin also lowers with extended fasting and rises from dieting.

Blood sugar and insulin are lowered when fasting, reducing inflammation and allowing the immune bodies to move freely through the body.

T cells are crucial in fighting cancer, autoimmune disease and infection. Tthymus generally stops making them with age but fasting releases stem cells, which then can become new T cells. It also releases growth hormone, which regenerates the thymus!

Fasting reduces cortisol over time and improves your circadian rhythm.

Reduces B cells by over half in a single fast, greatly reducing allergic and other autoimmune responses.



Fasts from 36-96 h increase metabolic rate due to norepinephrine release!.

Fasting increases interferon, which shuts down the ability of viruses to replicate.

Fasting does not reduce testosterone over time. It raises it when the fast is broken by increasing lutenizing hormone. It also increases insulin sensitivity, which helps with muscle building. And removes fat, which also increases estrogen in men.

Fasting activates autophagy (literally self eating). This recycles damaged proteins and foreign matter such as viruses.

Weight loss from daily caloric restriction has 1/4 to 1/3 of the weight lost as lean tissue while many studies show fat loss from 36 h fasts without losing any lean tissue!

It increases mitochondrial function and repairs mtDNA. Mitochondrial function also has the added benefit of increasing your metabolism, fighting infection and cancer prevention!

24h of fasting reduces leptin levels by half! This reduces leptin resistance, which impairs immune function.

Fasting restores NAD+, reduces NADH and increases nitric oxide release to open blood vessels.

Over time fasting normalizes stomach acid levels and during the fast acid levels go down to allow for the healing of ulcers.

Fasting reduces pain and anxiety by stimulating the endocannabinoid system, just like the effect of CBD oil

Lowering insulin via fasting virtually eliminates chronic inflammation in the body.

Fasting can help with MS, Depression, BPD, Autism and seizures.

The obese will lose loose skin while fasting, but the frail will have increased growth hormone release, which helps to make more lean tissue and reduce frailness.

When not in ketosis, the brain can only burn glucose, which produces a great deal of damaging ROS the brain has to deal with.

Fasts of 36-96 will not affect short term female fertility or affect menstrual cycle. They also may increase long term fertility for some women.

Fasting increases telomere length, negating some effects of aging at a cellular level.

Fasting releases BDNF and NGF in the blood, creating new nerve and brain cell growth. This helps a great deal with diseases like MS, peripheral neuropathy and Alzheimers.

Fasting stimulates apoptosis in senescent or genetically damaged cells, destroying them. Senescent cells are responsible for many of the effects of aging and are a root cause of the development of cancer.

Glycine and trimethylglycine (TMG) can also be useful supplements while fasting that won't break ketosis and have many benefits.

A fasting mimicking diet for 3-5 days in a row provides many of the same benefits as water fasting. FMD has about 200-800 calories, under 18 g of protein and zero net carbs.


What breaks a fast? Anything with protein or carbohydrates in it will break a fast but most teas and herbs are OK. Supplements and meds usually break ketosis due to fillers or directly. Some of them also irritate the stomach. Many meds are dangerous to take while fasting.

Exogenous ketones can aid with fasting, allowing some people with specific issues to fast in spite of them without worrying as much about hypoglycemia. They also help with dementia and many other issues even if you take them while not fasting!

Children, expecting or nursing women should not fast for periods longer than 16 hours. People with pancreatic tumors that excrete insulin or certain rare forms of hypoglycemia generally cannot fast at all or only with doctor supervision. T1 diabetics can also fast but it is more complicated and should be approached with caution as it could lead to ketoacidosis and done under doctor supervision. If you experience extreme symptoms of some kind, especially dizziness or tremors, then simply break the fast with a low carb meal.

Resources:


This list compiled by the user known as Pottenger's Human on youtube. Feel free to copy and paste this anywhere you like, no accreditation needed!

[canberroo]

You're such a great communicator of complex concepts, Doc. Thank you.

[pablopolski]

As a fellow molecular biologist and physician I would love to hear your take on the use of antehelmintic drugs in the fight against cancer.

[JYAN]

Prof Tom Seyfried has been at this for over a decade with numerous papers published. The problem is that very few people took his work seriously. And as Dr Jason Fung explains, cancer cells behave very similarly to that of bacteria

[shunyaspirit]

Thank you Dr. Raszek. Grateful you are back again.🙏

[leslyrae]

It's been a while Mikolaj. I'm no longer a health consultant and don't stay on top health information as much or follow you on Patreon. I'm so glad I caught this one! In my previous health field experience phosphorylation, ROS and mitochondrial dysfunction were all sorely ignored as factors in many illnesses, not just cancer. In my own research I identified an imbalance of glutamate to GABA as a primary factor in the development of mast cell affective syndrome. All of this comes back to Naviaux's cell danger response it seems and I imagine there are pieces here and there from many theories that are all true in regards to cancer. The limitation of allopathic medicine is the myopic compartmentalization that often leaves the true picture out of view.

[christineellengalbraith]

Dr Brian Clancy in Australia (father of immunology who set up Canada’s immunology specialism) & Dr Angus Dagleish UK have a new cancer approached “bacterio-immunology.”
Both speak on Dr John Campbell’s channel about their approach. Current hurdle is trying to get work published but it is a very inexpensive approach with no side effects so I guess there are many who would NOT want it to come to mainstream. Their development company is under threat from not being able to progress without funding.

[DogChowGurl]

I just realized how many times I have seen the seasons change in your videos. Thank you so much for all the great information. And hope.

[therealdrbyte]

Explains the ivermectin or fenbedazole results... apoptosis

[jimuren]

Dr Pierre Kory (substack, late 2024) and Nick Lane (book "Transformer" pub 2022 I think) also discussed this ... I was shocked to learn that this has been perhaps dominant for a decade or so but here in the layman world it doesn't get discussed much.
Good job, Dr Raszek!

[paultraynorbsc]

Thanks for sharing this Timely update Dr Raszek 🙏

[theozeus]

There are quite a few accounts of people getting rid of cancer or managing it well through diet and repurposed drugs. Sami Tugano, she has been a stage 4 colon cancer patient with metastasis on multiple organs for years now. She eats pretty much a Lion diet, next to no carbs, and takes fenbendazole as a glutamine uptake inhibitor. This is based on the metabolic theory. Now Ivermectine is also talked about a lot in the metabolic theory.

[felblades]

i missed your videos, welcome back to the 1984 platform

[mariecurie]

Give us today our normal mitochondria 🙏

[maggiemac]

So glad to see your videos again!! And this is amazing new info! Always grateful for you new and understandable videos.

[robertdennis]

Dr. Otto Warburg....the unsung hero of cancer research?

[ColonelStraker]

Thank you, Doctor, for your transparency and intelligent sharing.
ALSO for sharing your location name in the video description, for each of your videos!!!

[libbert]

The Journal of Orthomolecular Medicine: Volume 39, Number 3, 2024. "Targeting the Mitochondrial- Stem Cell Connection in Cancer Treatment: A Hybrid Orthomolecular Protocol. This paper has a hybrid protocol in cancer treatment.

[marymelnyk]

Why not use Fenbenzadole to stop the fermentation

[lizkeith]

just learned cancer cells can ferment glutamine and use for growing as well as glucose.