Modulating the DNA damage response: The role of cell cycle checkpoint inhibitors

Dr Shivaani Kummar speaks with ecancertv at AACR 2016 about cell cycle regulation by checkpoint inhibitors.

By utilising the same checkpoint mechanisms that prevent damaged cells from replicating to limit tumour growth and stimulate host immunity, Dr Kummar describes the clinical significance of targeting Wee1 kinase pathways.

With trials of combination therapies and single agents now entering phase II, she also reports on the toxic side effects and risks of adjacent cytotoxic therapies.