How mRNA Vaccines Actually Work | Inside the Vaccine

Two of the vaccines we have for COVID-19 have the distinction of being the first mRNA vaccines to see widespread use in humans. But how do they work, and how are they different from all the immunizations you got as a kid? Learn what makes them different in this episode of SciShow, hosted by Rose Bear Don't Walk!

Hosted by: Rose Bear Don't Walk

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[tippib]

“Thank goodness my cells can follow instructions better than I do, ” I said as I glanced nervously at my lopsided nightstand.

[billy_in_c]

Host: "You might see where this is going."
Me: Did not see where it was going.

[franklsuarez]

This is what should have been on The Learning Channel, not Ancient Aliens.

[bluetannery]

I love the mental image of my immune system receiving the antibody information and then just going "on SIGHT"

[osmiumbin]

Just found out that Moderna's stock listing name is actually MRNA, haha

[terramater]

COVID-19 vaccines are new, and it’s normal for people to have questions about them. The sheer amount of information—and misinformation—about the different vaccines can be overwhelming to anyone. It's nice to see that SciShow is providing well-researched information (in snackable length) about this important topic.

[OctoNico]

The cell be like "Look at the nice proteins I made UwU"
The immune system: "KILL IT WITH FIRE! NO MERCY!"

[hodor]

Hosted by: Rose Bear Don't Walk
woah. killer name.

[kj]

It’s pretty cool that we’ve (our conscious brains) figured out how to talk to our body/cells

[glassbirds]

The stuff that's happened with these has made me really into genetics and biology in general hehe 👁

Thank you to scishow, quarantine, and an awesome bio teacher for helping me decide on a career idea

[heskrthmatt]

TBH, my immune system is a little....aggressive. I was a little leery of teaching it how to do new and interesting things. But so far so good.

[zameize]

Cells can receive command and make stuff. Meanwhile me forgetting what I want to do in span of 10 seconds.

[mashrien]

LOVING that my favorite presenter (Rose[Bear Don't Walk]) is showing up a lot more frequently.
I know we're not supposed to have favorite presenters, but Hank and Rose really nail the presentation and are easiest to listen to while still retaining the information.

[oscar_charlie]

You guys need to tone down the jump cuts a notch or two. At least leave a pause between the sentences, the last word is barely over before the whole thing jumps to another sentence from a different take. Seriously, is it that difficult to record a multi-sentence paragraph in one take?
Rose has potential, but this rushed style doesn't suit her, a slightly slower pace and lower voice would probably work better.

[JustaGuy-pmub]

What happens when these antigens spikes cross the blood brain barrier and insert themselves into protein receptors in the brain? The CDC said they don't flush out of the brain. Just a question if we are allowed to ask anymore.

[maxmusterman]

Cant wait for bioluminescence shot to party in the clubs

[KnowArt]

But the question remains: How does it do all these things like entering cells and going to your ribosomes?

[wisdomofthewolf]

I'm concerned about the information at 3:46 in the video. Could we delve deeper into how/why/for how long "our cells display the spikes (which they coded from the mRNA) on their surfaces"?

[klownkilla]

this raised a lot more questions than answers

[michaelgonzalez]

This is a good video, but can you describe the process of cross presentation of the antigen (transcribed from the mRNA) in dendritic cells which is how we elicit the immune response and subsequent T/B cell memory in first place?