What is Neuronal Adaptation? (And Muscular Hypertrophy)

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A quick description of the strength adaptation neuronal adaptation from me, Doctor Owen, a Medical Doctor and Chemist.
The importance of neuronal adaptation is that it is a proven mechanism for improving strength independent of muscle size. Research has shown that neuronal adaptation is best stimulated through high-load, low-repetition training at, or close to, your one-rep max
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Are these adaptations lost due to not training for a long time, or are they permenant?

Adamkww