Metabolism | Fatty Acid Synthesis: Part 2 (Updated)

You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:

Join us for part 2 of this two part series on fatty acid synthesis. During this lecture we will be concluding our discussion on fatty acid synthesis. We will also be talking about how Malonyl-CoA is converted into 16 carbon fatty acids. We also talk about the main enzyme in this process called fatty acid synthetase and the different domains of the fatty acid synthetase. We hope you enjoy this lecture and be sure to support us below!

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[oliverkleim]

3:58 pyruvate has 3 carbons, not 2... I've been doctor for 23 years and studying again all of these issues. Thanks a lot for your help in this process

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[fernandoagzmarzo]

Excelent explanation!
Just a small obsrvation at 2:18
Citrate is transformed to Isocitrate by the catalysis of Aconitase enzyme, but this is not the enzyme that is regulated.
When there ATP concentration is high, Citrate Synthase is inhibited and Isocitrate accumulates, and since that the reaction from Citrate to Isocitrate is reversible, Citrate starts to accumulate as well.

[niluhansi]

I am a university student in Sri Lanka. I couldn't get any idea about FA synthesis before but now I have a perfect understanding about this. Thank you very much

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once again this guy manages to explain a difficult topic in a clear and enjoyable way

[szshz]

You're amazing brother. Really helping us med student here. You're the best Teacher we all dream to get in our Universities <3

[HajongLee]

I have been grappling with this all week, just trying to understand FA synthase. This is just gold. Plus it's been recently updated! How perfect!

All the powerpoint slides I have been given at med school was just useless...

Thank you and congratulations on your website launch!

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Love the way you explain things with so much excitement. I don’t even know how someone can keep so much information in his brain!

[cicelynicole]

Your videos are very detailed, easy to understand and informative. You make the pathways easier to understand. Thank you your videos are saving my grade in Macronutrients!!

[jg]

It seems you made a mistake. In 19:44 you said that 3 C atoms come from malonyl and 1 C atom from acetyl. According to Lippincott's 'Biochemistry' (2017) the atom in CO2 comes from malonyl, not acetyl, so eventually you get 2 C from malonyl and 2 C from acetyl. Cheers!