Human Brains Preserving the Brain - #1

Human Brains: Preserving the Brain – Forum on Neurodegenerative Diseases

Workshop #1
Neuroimmunology of MS
Yale School of Medicine

19 September 2022 from 10 am to 12 pm EDT

PROGRAM
David Hafler, Overview of the Cause of MS
David Pitt, Astrocyte and the Neuropathology of MS
Tomokazu Sumida, Loss of Immune regulation in MS
Erin Longbrake, New Clinical Trials in MS

ABSTRACT
There has been tremendous progress in developing working models underlying the cause of early, relapsing remitting multiple sclerosis (MS). In this workshop, we will begin by presenting an overview of this model, where genetics interacts with environmental factors leading to activated, myelin reactive T cells mediating autoimmune inflammation in the white matter. We will then explore the detailed neuropathology of MS and how astrocytic/microglial interactions drive neurodegeneration. How the environment induces dysregulated immune system allowing activation of autoreactive T cells will be followed by an overview of new clinical trials in MS.