Virology Lectures 2024 #6: Synthesis of RNA from RNA

Host cells have no enzyme that can replicate viral RNA or make mRNA, so virus genomes must encode enzymes to carry out these processes. In this lecture we discuss the mechanisms of RNA synthesis by RNA dependent RNA polymerases, including priming of RNA synthesis, how mRNA and genomes are produced in infected cells, and the switch from synthesis of mRNAs to genomes, for negative strand RNA viruses, positive strand RNA viruses, and double-stranded RNA viruses.

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I’m Vincent Racaniello, Earth’s Virology Professor, and I believe that education should be free.

I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

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[johnellmaker]

The past several lectures are a significant step up if you don't have a good grasp on prerequisites, but still has a lot of accessible information. I take time to rewatch whenever possible and it helps a lot, there's also a great deal of lectures around the corner that aren't so demanding so if you're in a similar boat and struggle with this stuff, carry on, there's much to come

[michelefournier]

These are so helpful thanks so much for recording these for us!

[zhansayabauyrzhanova]

i wanna ask, why influenza requires entry into nucleus, while VSV doesn't both are -strand RNA?

[zhansayabauyrzhanova]

my lovely lectures are 5 and 6. Here I am

[Naughts.and.Crosses]

Some RNA History
• 2024 - Columbian Professor pronounces IRGA...