Vesicle Fusion (Membrane Docking and Cargo Release)

Cell biology tutorial explaining how newly formed vesicles dock to their target membrane and fuse with membranes to release their cargo.

[pastelblaxx]

these videos really help me considering that my class does not have lectures at all and only requires us to read -.-

[fuchsi]

thank you for this video, very interesting! One thing seems odd to me: Shouldn't the SNARE Complex and the vesicle at 2:29 be located within the axon/at the presynaptic membrane?

[juliaschechter]

wow, excellent video. thank you for the clear explanation and accompanying illustrations!

[shubhambhelau]

Best illustration about the cellular process...Your videos helps students for easy imagination while reading....Thank you for this wonderful job...We need more of it 😀😀All the best for your growth 😄

[juanjuan]

Hello, thanks for the clip, very graphic and explanatory. I have a question though, you said something which confused me. In minute 2:42, you say "SNAP-25, forms coils with another t-SNARE called synaptobrevin, and the v-SNARE syntaxin". Isnt the other way around? t-SNARE called syntaxin and v-SNARE called synaptobrevin? Im sorry for the detail, but Im having a hard time figuring this process out. Thanks

[lukidurer]

Very informative and well-produced video, thank you! One question: if the Rab's are specific for different membranes, how is that specificity granted? Are the GEFs on the membranes selective for a corresponding Rab? If so, how does a target membrane get rid of the now incorporated Rab-GEFs after fusing with a vesicle that contained them to recruit their corresponding Rab?
Thank you in advance for any answers!

[valentineb]

Really interesting video but Syntaxin is a t-SNARE and not a v-SNARE, and Synaptobrevin is a v-SNARE not a t-SNARE.

[meriemcullen]

omg i realised ur voice sounds like kevin spacey's !

[morningcoffeepottery]

Isn't synaptobrevin a V-Snare? (not a T)

[adrienbrook]

I can't believe I understood this