Ivermectin trial, Oxford University

Ivermectin Arm of PRINCIPLE Trial Put on Hold?

MedPage Today, Merck
"concluded that the probability of ivermectin providing a potentially safe and efficacious treatment option for SARS-CoV-2 infection is low and have prioritized internal efforts towards the development of alternate candidates that provide a higher probability of success for the treatment of COVID-19."
"If clinical data emerge providing definitive evidence for a positive benefit-risk assessment of the use of ivermectin in COVID-19, we stand ready to provide our expertise and resources as needed,"

Ivermectin, PRINCIPLE trial

Professor Chris Butler, from the University Oxford’s Nuffield Department of Primary Care Health Sciences,

Joint Chief Investigator of the PRINCIPLE trial, said,

‘Ivermectin is readily available globally,

has been in wide use for many other infectious conditions so it’s a well-known medicine with a good safety profile,

and because of the early promising results in some studies it is already being widely used to treat COVID-19 in several countries.

International Standard Randomised Controlled Trial Number

When is the study starting and how long is it expected to run for?

March 2020 to September 2022

Favipiravir

Ivermectin

A double blind trial

Independent Data Monitoring and Safety Committee

Will pick up a signal for futility, superiority, or safety

Will let the Trial Steering Committee know

Then a final analysis can be conducted, followed by the release of results and data

[bandit]

The open hostility towards therapeutics has been one of the most troubling aspects of the whole pandemic.

[zenkakuji]

The planned duration of the trials (March 2020-September 2022) seems rather long to me for an existing set of medications. When one considers that newly developed medications for the virus had been able to have clinical trials complete in less time.

[cryptosunflower]

My doctor has used Ivermectin as her treatment since the beginning and she hasn’t had one patient even land in hospital. Timing is key she said. There’s a few people that have used it and all have recovered really quickly. Honestly it’s a crime that it’s been suppressed as a treatment

[nancya]

You Doctor, are part of the British National "Treasure". A true gift and the first place I turn to hear common sense and best practices. PLEASE keep up your great work. You are truly appreicated.

[danbryan]

Doesn’t Merck have a new significantly more expensive treatment available? Shock horror that they would try and deter people away from the medication that they no longer make a bunch of money out of

[breal]

This man should be in the position of healthcare leadership and oversight... if only we could have someone so honest and principled...

[benjacoby]

your commitment to educating is honorable... thank you, Dr John

[pinanolady]

This is my personal experience with Ivermectin. I got Delta last year and was put on antibiotics and prednisone but symptoms (vise-like pressure around my heart and couldn’t breathe) were so severe I was about to go to the ER. Thankfully, my doctor prescribed Ivermectin and within 24 hours of the first dose, my symptoms were reduced to a tolerable level. Did Ivermectin magically make symptoms disappear? No. But Ivermectin DID help me avoid hospitalization when antibiotics and prednisone were not sufficient. I say follow the money. I hope there are consequences for making medical treatment political. Lives were at stake here.

[trainstation]

If nothing else, this pandemic opened people’s eyes regarding the grubby and incestuous nature between the pharma industry, research bodies, and public health. It is a thoroughly unprincipled affair, and Dr Campbell deserves a medal for continuing to wade through this quagmire day in & day out.🎖

[alohadave]

I live in Mexico. We've been using Ivermectin since 2020, and as noted in another comment below, if given early, it has remarkable efficacy.

[pcs]

This channel is a breath of fresh air.

[louislaryssa]

My doc prescribed Ivermectin. I have several comorbidities. I went downhill fast when diagnosed; my O2 dropped, couldn't get my 102.9 fever down, blood sugar dropped, asthma attacks every few hours, and within 10 hours of my first Ivermectin dose my O2 went up, my fever started going down, & blood sugar leveled out. It's been three weeks, & my asthma is just now getting under control, but I was not admitted to hospital! I'm alive because of Ivermectin.

[nevillevan]

Have been watching this channel on and off for 2 years now. Just love how the dry, by the book, British Dr Campbell has got frustrated by the issues that have driven me bat crazy from early on in this piece. It is sober analytical characters such as yourself that will carry the day against the real misinformation. Bravo

[tonyag]

Here in the US I got Ivermectin twice from my doctor in the last year. The first prescription was just a 20.00 copay the second one which was for my husband 6 month's later and I had to pay 140.00 because the middle man raised the prices and my mom and pop pharmacy couldn't take my insurance coverage on it and loose over $100.00 It's despicable what the pharmaceutical industries over here in the US are doing. Also it's very hard to find a pharmacy to even fill the script. Ivermectin worked great and both my husband and I took it early as soon as we got a positive covid test and we went from really sick to completely better after just 3 doses. One thing my doctor told me was to take the Ivermectin with food if you're using it for covid. On the box it says to take on an empty stomach but he explained that is for worms not covid. It's criminal how they have kept this medication from people here in the state's and the media has demonized this drug and so many people died needlessly or ended up in the hospital when they didn't need to.

[cherylmockotr]

To Merck, the word efficacious refers to finances, not health, i.e. Ivermectin's potential to be an efficacious treatment is low... meaning its ability for creating profit is low.

[cbb_creationsceciliabaca]

Thank God I can purchase it where I live.

[mayelasanchez]

It’s widely available here in Mexico’s pharmacies. I’m surprised some important people said on the media it’s just for animal use. Years ago I got a skin problem and the doctor prescribed it. So I was taken a back when I heard it’s not for human use.

[MicStowe]

When a true gentleman & sincere healer has had enough of the disinfo and breaks out the DEMO. That was awesome. Thank you, Sir, you've been a blessing to me & my precious 97-yr old father.

[kamalaji]

Well done once again, Dr. Campbell. We all got the message. You are a great communicator in these times.

[knockers]

We've all been scammed and we're still treaing it like it's not a scam.