NHGRI's Oral History Collection: Interview with David Bentley

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David Bentley, Ph.D., is chief scientist at Illumina Inc., where he develops new DNA sequencing technology for fast, accurate sequencing of complex genomes. This oral history follows Dr. Bentley’s career, including his research in Nobel Laureate Fred Sanger, Ph.D.’s, lab at Cambridge in 1979, the early rumblings of the Human Genome Project in the mid-1980s, and Phase I of the International HapMap Project, an international effort aimed at finding common genes and genetic variations that affect health and disease.

The National Human Genome Research Institute’s (NHGRI) Oral History Collection features discussions with influential figures in the field of genomics and about the history of institute. Intended for researchers and scholars, each oral history contains information about science and medicine, biographical details and insights into the inner workings of the institution and its
initiatives.


Check out NHGRI's Oral History Collection at /leadership-initiatives/History-of-Genomics-Program/oral-history-collection.
  1. National Human Genome Research Institute
  2. NHGRI Oral History Collection
  3. David Bentley
  4. DNA sequencing
  5. Human Genome Project
  6. International HapMap Project
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01:34 - What inspired you at Cambridge and Oxford?
02:54 - How did you end up working with George Brownlee?
04:12 - What was Fred Sanger like and what was his influence on you?
05:57 - What happened after Cambridge?
07:50 - What was your work like at the Dunn School of Pathology?
11:15 - When did you become interested in medical genetics?
14:39 - When did you start hearing about the Human Genome Project?
26:15 - What was working with Maynard Olson like?
28:50 - How did you get to the Sanger Centre?
35:04 - What were the roadblocks that you saw?
41:30 - What did the coordination effort leading up to the draft genome look like?
50:39 - When did people start talking about SNPs in the context of sequencing?
53:44 - How did the SNP Consortium come about?
57:02 - How many SNPs did you think you would need?
01:00:44 - How did the working group structure work?
01:02:13 - How important was it to use CEPH samples?
01:04:46 - How was it working with Charles Rotimi?

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