Mechanism of action of digoxin

[ebubejosh]

This video is very wrong.... When digoxin blocks the Na / K+ ATPase pump it causes build up of intracellular Na causing inhibition of Na / Ca+ channel exchanger (which causes extrusion of intracellular Ca+ and influx of Na) so when it's inhibited you won't longer have extrusion of Ca+ so following action potential Ca+ flows in through L-type calcium channel to causes muscle & since the Na/Ca+ channel exchanger has been inhibited by intracellular build up of Na the Ca+ remains trapped in the cell resulting in dia mopping up by sarcoplasmic reticulum increasing the Ca+ store to favour more effective muscle contraction following a subsequent action potential

[rifahnoorchowdhury]

i think there is a mistake here. Increased Na ion inside the cell doesnt activate the Na-Ca exchanger rather it deactivates it .So it cant take out the Ca .It increases the amount of Ca inside the cell overall.

[crazyfunnyboi]

Please take down the video. It's very wrong.
1. Conc. of Ca was initially freely rushing inside the cell, so it's doesn't need the Na to go out in order to go in.
2. with the effect of Digoxin, Na conc. outside is very low (Na cannot go out since ATP pump was blocked), and since Na was low outside, it cannot go back inside for the Ca to go out thru Na/Ca exchange
3. Ca was trapped inside, hence, increase contraction of the heart

[arbiankarim]

This video is incomplete, The increase of sodium inside the cell will make less gradient of sodium between the intracellular and extracellular. Making the calcium sodium exchanger inactive which in turn makes less calcium pumped out of the cell. Digoxin is used to increase the calcium inside the cell by preventing it to be pumped out from the cell

[daniyabaksh]

Nice. Simple and effective plz make such videos of mechanism of action

[ashabulnaeemjony]

i love your graphics and animation . i love your work

[snehajohn]

It was very helpful ....made the complex thing to easy

[shvonned.burkemsncrnpagpcn]

Damn, that was an effective quickie ❣️

[heavythinker]

Such a shame!! Good graphics but TOTALLY WRONG INFORMATION! To those who will take their exams, don't even watch this.

[nikitathakur]

So grateful, I learned in feww minutes' amazing

[shaneignatius]

Ca na pump is reversed in this video...

[jkstudyhub]

Negative people say this video is wrong 🤬🤬🤬😡😡 Use heart in science not ur brain.
Keep on spreading positivity dear positive people 🥰 THIS VIDEO IS ALL GOOD. BE POSITIVE 🥴

[KhaledAmgad]

No, you should have delete the video
it's wrong and thus can cause confusion for students