David Sinclair on NMN Minimal Dose and BEST Timing

David Sinclair explains what’s the minimum NMN dose and the best timing for taking NMN supplement.

If you take NMN or consider taking this supplement, this is a crucial information.

🔴Want NMN Protocols to skyrocket your NAD plus extra Bonuses?

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Disclaimer & Disclosure: The information in this video and/or at this channel is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge, educational and information from the research and experience of Rimon, who encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.
Rimon is not a medical doctor. If there is a contradiction between the advice here to your doctor or local authorities, always go with the doctor and the authorities.
Statements made, or solutions suggested in this video and/or at this channel are not intended to diagnose, treat, cure, or prevent any disease.
The statements are not contradictory to first following authorities' guidelines of social distancing and hygiene.

[WellnessMessiah]

🔴Want NMN Protocols to skyrocket your NAD plus extra Bonuses?

[jennifermcrayde]

I'm 41 and been taking NMN + Resveratrol intermittently, for almost 4 yrs. Keep in mind, I never took more than 500mg. Thorough out those years, I probably took around 240mg every day for about 4-5 days, break a couple days, then now, I am trying out 500mg NMN + 80mg Resveratrol and 500 TMG every other day. I take every other day because one...I'm fairly small framed - 5'3.5" and 95 lbs. and also, I work out often and don't want the resveratrol to interfere with that, so I always take NMN and resveratrol within an hour or so of each other (Rsver. with mixed nuts for absorption) after my cardio and lift sessions around 11am. Timing of that seems to be going well, and not affecting sleep too much.

[SuriaMohd]

I take 1g a day breaking it into 4 parts. I take 2 types NMN with Antioxidants & NMN on its own. It is helping make my skin feels tighter & firmer.

[jaykamhi]

NMN makes me tired if I take in morning. A close friend told me the same thing. Late afternoon/early evening seems to work best for me. There's a Japanese study that seems to confirm this timing for older people.

[projimbo]

Best timing seems to be when David lifts his request to the FDA :(

[revarae]

I started taking RBS sublingual NMN under the tongue about a month and a half ago, it made me extremely groggy the first week and I almost stopped completely but I pushed through and by week two I wasn’t experiencing that anymore. I also take TMG, Resveratrol, Quercetin, and Spermidine. I’m going to add Berberine and NAC to my supp stack soon too.

[kevinbadalkar]

Hello Dr. Sinclair, is it true that if we take NMN, we also have to take TMG (trimethylglycine) as otherwise bad effects from methyl donor depletion occurs? Most of your videos do not mention TMG but i heard this by other specialists.

[bogdantoma]

A series of 12 studies on a molecule called NMN (Nicotinamide Mononucleotide).

The conclusions are the following:

- NMN supplementation does not increase muscle NAD levels, which contradicts the theory that NMN supplementation can boost NAD levels.
- older adults who exercise have similar muscle NAD levels to younger adults, suggesting that exercise is essential for maintaining NAD levels.
- NMN supplementation did not show significant improvements in various measures of health and fitness, including body composition, blood sugar levels, insulin sensitivity, sleep quality, fatigue and exercise performance. Although NMN supplementation appears safe, its benefits are not as robust or compelling as some might expect based on the influencer hype surrounding NMN.

Studies on NMN supplementation have shown mixed results. Most studies have shown no improvement in muscle performance, body composition, blood pressure, cholesterol, or insulin levels. In fact, an increase in insulin levels was seen in one study, which is not a desired outcome.

Although NMN appears to be safe and increases blood NAD levels, it does not appear to improve muscle NAD. There is no improvement in VO2 max, strength, walking speed, sleep, fatigue, well-being, hearing, cognition or arterial stiffness.

In conclusion, human studies of NMN have been largely disappointing. The benefits experienced by social media influencers praising NMN are likely the result of better diet, exercise, and adequate sleep—that is, a placebo effect.

Additionally, there is evidence that NMN and NR supplements are broken down by our gut microbiome and not directly absorbed. Any small amount that is absorbed and enters our bloodstream is quickly broken down by our liver.

So while you may choose to buy NMN supplements, you should know that the benefits may be limited.

[mhaas]

I been taking 250 mg in the morning with coffee for about a month. I do feel very good, high energy, alert, focused, very minimal aches or pains, sleep is good and I do not wake up feeling tired. but this could be from my healthy eating and almost daily 5 or more mile morning run.

[soylentmajority]

I have a question: If Sinclair discovers we can still get nmn from overseas, despite his ban, would he call the police?

[cassamoalibadrudinocassamo]

Nmn has any drug interactions with Xarelto 20?
I am 75 Year old. 250 mg per day will bring any benefits?
Is there bleeding risk 250 or 500 mg MNM in the morning and Xarelto during dinner?
I would appreciate your help.
Thank you

[DUDIDUAN]

NR is the more efficient molecule because of its smaller molecular size offering direct cell entry and more Nad+ density per mass. And it is safer as Niagen has more extensive human studys and a more reliable supply chain. But NR is patented, so the NMN are manufactured in China and packaged in the US by numerous small firms without any patent infringement and the industry did massive marketing. Basically, people are buying less efficient and less reliable NMN simply because of its massive marketing budget.

[tatyanadarius]

What is the best brand NMN? There are a lot on market, it’s confusing.

[ionescuelectra]

I wouldn't recommend taking it in the evening unless you intend to pull an all-nighter. Sometimes I have to work a 32 or even a 40 hours shift (intense intelectual work). After 24 hours usually brain fog would set in but this time I took NMN and lo and behold brain fog didn’t set and mental alertness was normal in even at the 40 hours mark. I took my usual dose of 750mg in the morning when I started my shift, and then 500mg after 16 hours, another 500mg after 24 hours, and finally another 500mg after 32 hours.

[Alan]

Does NMN works on dog ? My dog is 16 years old and suffering from heart disease, will NMN help ?

[davidrowan]

So whats the deal with this and reservatol? Do you take 1g of each daily? Or can you take less if taking both?

[bernhardwalther]

Interesting again. So D. S. takes 1g NMN in the early morning. There is an interesting talk on the minimum dose of NMN. I hope people designing the next NMN trial will take it into account and and go over 250mg as it appears difficult to have significant results by staying at the minimum of dose and time.

[larsnystrom]

It seems that NMN raises the level of NAD and it's metabolites in blood.

But why?

I thought the model were that NMN would go into the cells, and there be converted into NAD+.

Furthermore, that NAD+ can't enter the cells. So what use is it in the blood?

It seems that the level of NMN doesn't increase in the blood. At least, no one has said it does.

[denisefuentes]

I bought good quality NMN and took 125 mg daily for two weeks. Omg! My liver or gallbladder got progressively more painful or achey. As soon as I stopped the pain stopped. Is it just me?

[carietownley]

Hi Rimon, can you please guide me? I implemented David Sinclair’s supplement 2023 with the only difference using berberine instead of metformin. Week 5 in I had an allergic reaction, a prickly, itchy red rash started on my hands, it spread up my arms, my face became red and swollen, from my eyebrows to the corner of my eyes went black. The redness and swelling was on my neck down onto the top of my chest. I stopped everything for nearly a week and everyday it slowly calmed down. These were purchased through donotage, so a good provider. Did I overload myself my taking everything at high levels straight away and should I have very slowly started these implementing them slowly one at a time. Your guidance would be greatly appreciated because for a time in the middle say within 2 weeks I felt fantastic…