Does animal protein shorten our life span? With James Clement

James W. Clement is a lawyer and entrepreneur turned research scientist who has devoted the last two decades to understanding the science of life extension. He is best known for his Supercentenarian Research Study, which he started in 2010 with Professor George M. Church of Harvard Medical School and has received international press coverage. Through worldwide scientific collaborations and in his own laboratory, James focuses on advancing cutting-edge biomedical discoveries. He is the founder of the nonprofit Betterhumans biomedical research organization. Led by a collection of high-profile researchers, the organization focuses on bringing cutting edge scientific discoveries from the lab to the clinic. Clement was the 12th person in the world to have his whole genome sequenced and is Personal Genome Project participant #145

Time Stamps:
10:36 Start of podcast
11:16 What type of research is James doing and how does it relate to aging?
13:21 Compression of morbidity.
24:16 Feedlot meat and processed foods (24:16-25:01)
26:16 Super centenarian studies.
29:17 Observations on what super centenarians have in common.
32:06 Laron Dwarfs and IGF1 (32:36-33:11)
33:56 Should we over stimulate IGF1?
37:36 Measuring IGF1
40:06 Blue Zones and centenarian diets
43:16 Intermittent Hypoxia
47:06 Over fasting, finding a good balance.
52:06 Environmental hormesis
53:16 Okinawans
56:06 Confounding variables.
1:00:51 mTor/ketosis and glycogen depletion in the liver.
1:04:06 Animal based diets and intermittent ketosis.
1:06:36 James' thoughts on the carnivore diet.
1:11:21 Lack of nutrients in a plant based diet.
1:12:56 Benefits of prolonged ketosis in morbidly obese.
1:16:36 Protein sparing modified fast benefits.
1:20:36 Calorie restricted pure vegan diet.
1:22:26 Dexa scan.
1:26:16 James's insulin levels.
1:28:06 AGEs (advanced glycation end products)
1:35:36 Stress and glucose levels.
1:39:16 Does too much protein harm the kidneys?
1:45:36 Protein cycling.
1:47:00 Occasional long term fasting benefits.
1:48:01 Loma Linda sperm quality.
1:50:06 Carnivore diet for longevity.
1:52:46 Issues with studies comparing meat eaters vs. non meat eaters.
1:54:26 The most radical thing James has done recently.

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SOCIAL MEDIA
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[robinbeers]

Sorry, but I have trouble taking advice from someone who claims his vegan diet is great but takes "20 supplements a day" (his words).

[jc]

omad with carnivore "ish" diet for me
cured my:
1. high uric acid
2. high triglycerides
With my freestyle libre its lights out,
I have never been more free <no more meal preps>
I have more energy and mental clarity, than before.
I am N=1 but there are alot of N =1 ... that creates a cohort no?

[craigw]

Hmmm, rib eye or hypoglycemic broccoli/cabbage. Easy choice for me. The rib eye will last me all day. If plants are so good, why does he need supplements?

[mikieemiike]

I remember losing my train-of-thought when I was on a vegetarian diet, also.

[lucasalshouse]

Every time Paul talks I'm thinking "that makes so much sense!". Every time James responds I'm thinking "Did he even hear what Paul just said?".

[CraigCastanet]

Dr. Austin Baraki, an internist, and powerlifter, of "Barbell Medicine" Youtube fame, has discussed protein and kidney function at length. Even for kidney-diseased patients, a poverty of protein is more dangerous, due to the ensuing sarcopenia, than the processing demands they will place on their kidneys. You can find his informed lecture for physicians on Youtube.

[daposevvg]

I appreciate Paul bringing on these intellectual Vegans like Sinclair and Clement. They are reminding me through their spaced out slow talking interviews of why I quit being vegan. No energy slow speech. Cant finish a sentence without saying, eh... ah... um... what was I talking about? Eh...My brain was thinking about vegan keto donuts... Um? Oh. eh... 
All these guys like Longo are not models of health in my superficial observation. Thanks Paul for not letting these guys off easy on their bullshit miss representation of the science.

[mirjammaver]

eeem, eeeem, eeeem - that's how I was speaking when I had been vegan for some time and then I went back to being omnivore and it did't help my damaged body. When going carnivorish I was finaly able to speak fluently again. Is there actually any LONG TERM vegan that can actually speak fluently? I just find it hard to believe that you are healthy if your brain si damaged to such a degree. And don't tell me that all those difficulties speaking are not some sort of brain damage. And I'll have to go with Amber O'hearn that supplementing fucks up nutrients ratios. When you add a little bit of that, then you additionally need a little bit of the other thing and so on and so one. Needing 20 different supplements is just fucked up. How can anyone sane propose a healthy diet with 20 supplements is beyond my understanding, much less so that person being a scientist.

[terraflow__bryanburdo]

1:06:30 "Umm my grandparents ate bacon and eggs and meat and uhh lived to be mid-90s and umm but uhh I am ummm so much smarter i uhh am going to umm live to be infinity umm because I uhh know about umm mTOR and uhh take 20 supplements and ummm ... lost my train of thought ...."

[traylaitken-cade]

Great interview. I watched Paul interviewing Cyrus and Robbie and I learned a great deal . The way forward is bringing together opposing views and listening to the science that supports their protocols . These Doctors are all passionate about health and even though their approaches differ they can all give loads of patient testamonials that show positive outcomes . Thankyou very much for this platform Dr Paul .🐂🐖🍓🍅🐠🥑🥦

[rusjacobson]

Thank you for what you do, Paul, and I am experiencing good results with a mostly meat diet.
I do have a bone to pick, as it were, though over your comments about Co2, carbon,etc., and your concern over it. There is no concern to be had over this and I think it would be helpful if you talked to scientists that can help educate you and others on this topic. In short, Co2 is not an issue to worry about and it is not causing climate change.

[eltigre]

I just finished this one on my phone while walking. This was an AWESOME podcast Paul. Packed with lots of great data points. VERY INTERESTING points about smoking and hypoxia the hormetic effects it has. The 108 year old people smoked! James Clement was quite knowledgeable. I'm gonna get his book. I would be very interested in studies regarding carbohydrates versus protein, which raises IGF-1 more? When you search the web it's hard to find articles about carbs raising bet is processed carbs raise it more than protein but nobody will admit that. I think you guys agreed on 95% of the things discussed. You guys were quite civil which I always appreciate. I like the idea of cycling growth(IGF-1 and mTOR). It certainly makes sense that the SAD diet keeps IGF-1 on all the time. This is yet more evidence that I need to change my diet and control my eating hahaahaa! No more ENTIRE large cheese pizzas for me at dinner( or lunch of any time of the day hahaha!). I'd love for you to do a podcast with Peter Attia, mainly because he was critical of the carnivore diet and I'd like you to put him in his place! Plus, he also said to eat JUST enough protein to maintain a positive nitrogen balance, but no more than that. Problem is: There is no test to see if you are in a positive nitrogen balance that I know of? Maybe check BUN levels? Maybe if you are on the low end of normal in your BUN readings? How would you test that Dr. Paul?

[Gianluca]

Related to cutting the trees: it is also true. That extra physical exertion require some extra carbs/ calories, falling to give the body so, will produce the release of extra cortisol to make in fact glucose, that on a empty stomach will amplify at a greater degree the cortisol spike, therefore the circulating blood glucose. Stress require some extra glucose, being stressed out on a glucose burning body, could be synonym of not eating enough glucose

[DT]

"Umm....uhhh....umm" I'm really curious what causes this in people. This James guy has it pretty bad.

[CraigCastanet]

Clement looks quite sarcopenic to me. I've been preoccupied with strength my whole life, because it seems the most valuable trait for all body systems.

[stevennoren]

It's all about choice you make your mind up of what works for you and find balance.

[peterz]

@33 so what are optimum IGF-1 levels by age? I can't seem to find this in the literature.

[CarnivoreDMD]

I’m having a hard time getting over the bad taste of grass fed steak. Seems ground beef is fine but could it just be a local issue and the type of grass or even seasonal?

[craftyHPLover]

That's what I'm working on currently: in the last 8-12 months my BMI dropped about .75% (I've had bloodwork, an MRI (for na fatty liver) and a Dr's visit all in the last two weeks. My fatty liver is currently stable but my weight has come down a bit (I just started about 6 weeks ago). I'm seeing him again in July, and getting bloodwork again in June. By that time there should be significant progress.

[coffeemachtspass]

My extended family in the central Andes enjoys excellent health as long as they avoid modernized ‘food’ (food-like products): rice, flour, seed oils. The most common reasons for ill health are accidental death (auto accidents, falls) and infections that aren’t treated early.

I suspect they’d live much longer than U.S. Americans if they cut out the sugar, went back to their native foods and got doctors’ visits for the infections.