Apoptosis (Intrinsic, Extrinsic Pathways) vs. Necrosis

My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
For educational purposes only; NOT medical or other advice.
Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
Opinions are entirely my own.

[DirtyMedicine]

Errata: perforin is the substance that creates the hole, Granzyne B is the substance that activates Caspase

[MohamedOsama-nyix]

promise im gonna support this channel once im done being broke

[FarrOutt]

I am in MED school, I didn't understand this concept during Pathology Lecture but I manage to get it with this 15 mins video....Thankyou so much...

[bluejay]

Bcl stands for "B cell lymphoma"
(just another way to remember that bcl = anti-apoptotic)

[theonejackal]

Not only do you explain it summed up in a simple way, but also you make it easier to remember!

You've earned that like.

[vitezslavduda]

Mate, thank you so much for your work!
I'm studying pharmacy and many of your videos are extremely helpful for my revision. Especially the ones focusing on pharmacology, so I'd definitely appreciate more of those. The mnemonics you use are amazing and helped me loads. So glad I found your channel.

Keep up the good work :)

[MultiNerve]

BAC or BAX has an "A" in it (duh, ) which can stand for "Apoptosis" --> these cause apoptosis in the intrinsic pathway

[drdoolittles]

You certainly have a way of making complicated processes a lot easier to understand 😊

[pacifistermek]

thanks a lot u made my journey through USMLE whole way easier

[ArtGallery-rcwy]

12:50 lmao this cracked me up . I just googled it right before he asked to and it made more funnier 🤣🤣🤣

[YellowBellow]

Love it! My tutor recommended 👌🏽 y'all are both lifesavers.

[foreverxfall]

What about the specific caspases that are involved in the processes? For example, caspase 2, 8, 9, 10 being initiator caspases

But also caspase 9 being a key player in intrinsic apoptosis. On that note, it it important that we know the function of Apaf-1?

[dr.reddyhoff]

perforin 'perforates', granzyme B enters. (big fan of your channel here :) )

[jacobhernandez]

VERY HELPFUL thanks once again for these awesome videos

[aishahussein]

U made my life so much easier thank youuuu

[arileinkalra]

I guess the mnemonic could change to the "Toxic Perm on Granny" for extrinsic pathway!

[frostedgraves]

Perforin forms pores on the cell membrane and then granzyme enters through the pores.

[insidenumber]

It was so helpful thank you may god bless you 🙏🏼

[bslaozora]

Not a US student and I have some genuine questions...No offense@@

Is that really enough for getting all the USMLE? I mean like, no need to know exactly which caspase (9, 8, 3...) and how 7 pairs of cytochrome C and APAF1 forming apoptosome, which cleaves procaspase 9 into its active form blablabla...(And other details I don't rmb/I didn't learn)
Or these stuff are examined within the medical school so not on the USMLE?

[degoldessie]

Excellent @dirty medicine, I like your Mnemonics