ACUTE PYELONEPHRITIS- Pathology

ACUTE PYELONEPHRITIS- PATHOLOGY
Acute pyelonephritis
Acute pyelonephritis is defined as suppurative inflammation of kidney and renal pelvis
Caused by bacterial infection_ most commonly gram negative bacilli- E Coli.
Recurrent urinary infections are more common with Proteus, Klebsiella, Enterobacter, and Pseudomonas.
The bacteria reach the kidney most commonly by ascending infection, from the lower urinary tract. Instrumentation, Vesicouretric reflux are the predisposing factors
Hematogenous spread in the next common cause, in cases septicemia or infective endocarditis.
Morphology:
Gross: one or both kidneys are involved, which can be normal in size or enlarged. Tiny abscesses, which are raised yellowish lesions are apparent on the renal surface.
Microscopy:
Liquefactive necrosis and collections of neutrophils are seen in renal parenchyma
Numerous intratubular neutrophils are seen in the early stages which can extend into the adjacent interstitial tissue in the later stages.
The glomeruli are spared usually.
Acute pyelonephritis: This is an example of ascending infection in which there is prominent expansion of collecting ducts in the medulla region. All the lumina are filled with neutrophils. The epithelial cells are barely discernible. The interstitum is also edematous and filled with neutrophils. ( A: H&E X 250, B: H&E X 400 )
Complications – Pyonephrosis: filling of pus in the renal pelvis and ureter due to obstruction.

[clementmuchimba]

Blessings to you Doc
Content understand with precision
Thank you

[piousmedicos]

how can we understand other topics of kidney pathology please make vidoes of all topics of special pathology we love these vidoes

[naaengmann]

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[tinotendamakaure]

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[shaiklathifmunnisha]

Thank you so much for such good explanation sir

[mohdahmad]

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[তিথিফাহমিদাসুলতানা]

Thank you for ur video. It was very helpful.

[akhilkumardas]

Crystal clear concept
Thank you Sir 🙏🙏

[smitadeshmukh]

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[desalegngirma]

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[VENKYVOICE]

I’m facing this issue and Ultrasound says that i had pylonephritis. I had random pain at both kidneys and going for frequent urination ( without bladder fillup to ), some times I observed Foaming in urine. I’m 27yrs old.no painful urination or fever

[piousmedicos]

please complete all topics of special pathology

[rahmed]

Sir what your refrance please
Thank you❤

[pavunkumar]

Please put videos on heart and blood vessels

[mohdahmad]

Please give video on nephrotic syndrome

[abdulmubeensyed]

Sir pls do diabetes mellitus .it's a sincere request sir .

[rajasrivangala]

Hi sir, my mother facing this problem. She is 60 years old, diabetic from 10 years n from 15 years suffering from acidity indigetion
First lose motions started stomuch pain then urine burning then urine stopped, water vomtings
In ultrasound grade1 parenchymal disease
CT KUB ipsilateral pyelonephritis found
She is taking antibiotics from 20days
Sir please suggest me how it will be cured.. N she is having still vomit sensation