Myositis Specific Antibodies

Hannah Kim, MD, discusses Myositis Specific Antibodies, and then she and Sarah Tansley, PhD, take questions from the audience.

00:18 What Is JDM?
1:05 What Is a Biomarker?
1:41 How Does the Immune System Work?
02:55 What Is an Antibody?
05:50 What Is a Myositis Specific Autoantibody (MSA)?
06:54 Why Are MSAs Important in JM?
09:00 Specific Examples of the MSAs
17:03 Less Common MSA Groups in JM
21:40 How is MSA Testing Done?
26:47 Summary of Information
28:32 First Audience Question - If a Weak Muscle Band Is Detected and MJ Is Suspected, Do You Recommended a MSA-Specific Test?
30:05 Testing for MDA 5 Early in Diagnosis?
32:00 Do You Re-Test After Inconclusive Results?
34:15 Should You Push for Your Child to Be Tested For MSAs?
36:11 Is There a Connection to Adult Cancer?
39:23 Do You Have a Sense of the Percentage of the Pediatric Rheumatologists That Know to Run These Tests?
41:49 Role of MSA Testing in Predicting Disease Manifestations Not Present at Diagnosis
43:27 Dr. Kim Expounds on Question About Cancer and JDM
44:48 Are There Typical Characteristics of RO 60?
45:27 Can Drug Treatments Protocols Affect MSA Results?
46:50 My Son Has Had JDM for 10 Years and No Remission, Do You Recommend MSA Testing?
47:54 Which Antibiodies Are Associated with JM?
48: 40 Dr. Kim Clarifies Question About Whether She Recommends Testing for MSAs
49:12 Test Results Changing Over Time?