Biohacking the Oral Microbiome

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Papers referenced in the video:

A Brief Introduction to Oral Diseases: Caries, Periodontal Disease, and Oral Cancer

Xylitol, mutans streptococci, and dental plaque

Growth Inhibition of Streptococcus mutans with Low Xylitol Concentrations

The antimicrobial activity of essential oils and essential oil components towards oral bacteria

Nitrate as a potential prebiotic for the oral microbiome

[DonnaLHaney]

Mouthwash recipe:
1000 mL water
10g xylitol
10g baking soda
2 drops peppermint oil
2g potassium nitrate
CORRECTED, see Michael's comments 👇

Also in other's comments here I see that sensitivity toothpaste contains high levels of potassium nitrate (but along with other chemicals), and some suggest that clean Listerine might also be beneficial for killing bacteria.

[alanmunro]

Great content. I have long-standing gum disease and it is controlled by
A) regular dental hygiene visits, 4 per year
B)using a waterpik machine
C) adding hydrogen peroxide to above
D) taking a prebiotic supplement
I will be encouraging my dentist and functional medicine doc to view this video.
Many thanks.

[KoiRun]

Interesting to know about the beneficial bacteria involved. I like reading about these bacteria. Even before the pandemic I’ve been rinsing and gargling with clove oil. So far so good. I would really like to keep all my teeth (and taste buds) till a ripe old age because I like eating^^

[DonnaLHaney]

I drink teas throughout the day.☕ In the morning I do a chia type tea with cinnamon and cloves. Later I switch to peppermint tea. I used to add xylitol to the peppermint tea, but discovered that ingesting xylitol raises my blood glucose (contrary to common opinion, based on my CGM).

[peterz]

Excellent! Thanks Michael. Will be making some changes. And testing. Already eating a high nitrate diet and use higher pH water (~8) to make tea and coffee.

[viracocha]

Wow! What a great video.
Beets look like a supperfood now :)

[iwdfsoo]

Doctor, how do we eliminate the bacteria that cause chronic bad breath and replace them with beneficial bacteria?

[frankfromupstateny]

Great video...very objective data. Ill be chewing on "beets" now throughout the day.

[KoiRun]

I liked it already because I just know I will. Can’t wait.

[luckssj]

I use a prebiotic, vitamin C, and D3, K2-MK7 and Co Q10 toothpaste and this keeps it up to a 5.5 ph.

[justsaying]

Thank you Michael. This is very interesting. You should turn your mouthwash into a commercial product and sell it.

[twoCleopatras]

Very interesting about pH buffering ability, thanks!

I've been brushing with Auromere toothpaste, it has many ayurvedic herbs traditionally used for oral health, many of which have effects on the oral microbiome (e.g. Neem). I wonder if your rinse could be improved further with additions from traditional pharmacopeia...

[daviddimbleby]

I'm making the mouth wash, thanks dude

[andrewtaylor]

This is very informative. Based on this, I take it that you have data that Xylitol does not damage the "good" oral bacteria, that is, the bacterial involved in nitric oxide production.

[petermilian]

My oral care routine after meals is to rinse for two minutes with a concentrated green tea solution (1/2 tsp powdered sencha in 60ml 165f / 75c water), then chew xylitol gum that uses a natural chicle / non-synthetic gum base (Tree Hugger) for 20-30 minutes, and then brush with a toothpaste using xylitol (Bite). What are your thoughts on this routine?

A lot of xylitol studies use xylitol gum after meals where the chewing action / saliva circulation post meal may be just as important if not more so than the xylitol itself. Why do you think a xylitol mouthwash is a better option than a xylitol gum or toothpaste?

It'd be way cheaper and less hassle if I could just add 1g xylitol to the green tea solution and skip the gum, but I'm not convinced I'd get similar benefits.

[nebojsa]

The most important question that no one asks. Will Xylitol, sodium bicarbonate, clove oil, peppermint kill GOOD BACTERIA???? Will it kill everything. If it does, you do more damage then benefits.

[JohnSlack]

Really cool idea to add nitrate to your mouthwash. What do you think about using calcium nitrate instead of potassium nitrate so that you can get double benefit by having the calcium ions remineralize your enamel too?

[davidthompson]

Thank you for another great contribution, and I really appreciate the siding of all the papers in the links, your logic behind the levels and how you approach the application of the knowledge to your own personal situation. It's a great example of how to apply with wisdom accurate knowledge. It would be interesting to see if environmental factors in the oral biome affect Downstream biome and then second order effects from that in terms of health and other processes in the body. I have read about biome transplants and that the younger biome being transplanted into an older patient can make that organism mimic a younger one, and it would be interesting to see if reducing our oral biome age, so that it resembled a Young Person's most idyllic oral biome, would that be a factor in reducing our biologic age?

[PocketSunlight]

Hi. Maybe you cover it in another video (I've only seen this one)? You don't mention Vitamin D3/K2 (some say take 10, 000 IU of D3 with 100 IU of K2 daily), generally for immunity and bones - which would further assist the Oral Microbiome. Just thought I'd mention it.

[mtrps_]

my goal this year is to have more neisseria