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TESTOSTERONE vs. DHT : Can testosterone directly cause Baldness? | COMPLETE GUIDE
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male pattern baldnes is due to DHT the active metabolite of Testosterone. But as evidenced clinicaly, does tesosterone have a direct role to play as well? Androgenetic alopecia causes explained in great detail by Dr Bhatti, hair transplant surgeon who runs darling Buds Clinic in Chandigarh, India.
There is no doubt it is a genetic problem but does DHT cause baldness and is there a role for testosterone acting independently to express its effect on the androgen receptors on the scalp?
People note low DHT levels and high testosterone levels in people who may be bald.
Patients using DHT blockers even Dutasteride that blocks 95% of DHT still are not happy. In these patients, though DHT is rock bottom, but testosterone levels are high.
So is there a direct role for testosterone in baldness. Or is it mere upregulation or downregulation of androgen receptors that causes the continued hair fall even with DHT blockers.
Well the jury is still out on this complex topic.
Just a quick recapitulation to revise our knowledge about male hormones and baldness.
Testosterone is the male sexual hormone and the majority of it is present in the blood stream bound to SHBG. And a much smaller amount called free testosterone. Free testosterone is what is available to us to exert its benefits to organs like the prostate, the scalp, the bone and joints, the the synaptic and dendritic pathways of the brain, etc.
We also know that 5AR enzyme is crucial to convert testosterone to DHT which acts on the scalp and prostate tissues alone.
Well, nature has various ingenious mechanisms and they all exist for a reason.
It has been seen that males with 5α-reductase deficiency developed ambiguous genitalia or female external genitalia at birth. They also had poor development of the prostate. It was also noted that these 5AR deficient children went on to have normal bone & muscle development during the pubertal transition phase of development. So from the phenotype of 5AR children it was inferred that the enzyme 5α-reductase is crucial for the development of the prostate and male external genitalia.
But what we see in clinical practice does suggest that 5α-reduction of testosterone is not obligatory for mediating androgenic effects in tissues in men. It has been seen that people who are 5AR deficient do continue to bald.
So the commonly held theory that testosterone needs to be converted to DHT has loop holes. It can be logically inferred that testosterone and DHT can both exert androgenic effects in all androgen-sensitive tissues. That their relative effects in any tissue are contingent upon their relative concentrations and potency.
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Know the World's TOP 20 hair transplant surgeons:
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Check these VIDEOS out as well:
CARE AFTER HAIR TRANSPLANT FOR FULL RECOVERY:
COST OF HAIR TRANSPLANT:
SEXUAL SIDE EFFECTS:
WHEY PROTEIN & HAIR LOSS:
SAW PALMETTO & HAIR TRANSPLANT:
SHARRY MANN HAIR TRANSPLANT-
WHY CROWN / VERTEX HAIR TRANSPLANT FAILS:
SAFE PROTOCOLS FOR BODY HAIR TRANSPLANT:
_____________________
OUR CLINIC (SAFETY FIRST):
_______________________
FOLLOW ME!
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This is Dr Bhatti's Darling Buds Clinic. Our YouTube channel is a destination for those researching Hair Transplant and other remedies for hair loss. We make videos to showcase our hair transplant results on the web through YouTube; all techniques available for hair transplant; and advances in the field of hair transplant are often dealt with.
________________________
PRODUCTION CREDITS
All videos are shot, edited and uploaded by the Darling Buds Team
________________________
________________________
Call or whatsapp us at: +919814531111
#testosterone #baldness #DHT
There is no doubt it is a genetic problem but does DHT cause baldness and is there a role for testosterone acting independently to express its effect on the androgen receptors on the scalp?
People note low DHT levels and high testosterone levels in people who may be bald.
Patients using DHT blockers even Dutasteride that blocks 95% of DHT still are not happy. In these patients, though DHT is rock bottom, but testosterone levels are high.
So is there a direct role for testosterone in baldness. Or is it mere upregulation or downregulation of androgen receptors that causes the continued hair fall even with DHT blockers.
Well the jury is still out on this complex topic.
Just a quick recapitulation to revise our knowledge about male hormones and baldness.
Testosterone is the male sexual hormone and the majority of it is present in the blood stream bound to SHBG. And a much smaller amount called free testosterone. Free testosterone is what is available to us to exert its benefits to organs like the prostate, the scalp, the bone and joints, the the synaptic and dendritic pathways of the brain, etc.
We also know that 5AR enzyme is crucial to convert testosterone to DHT which acts on the scalp and prostate tissues alone.
Well, nature has various ingenious mechanisms and they all exist for a reason.
It has been seen that males with 5α-reductase deficiency developed ambiguous genitalia or female external genitalia at birth. They also had poor development of the prostate. It was also noted that these 5AR deficient children went on to have normal bone & muscle development during the pubertal transition phase of development. So from the phenotype of 5AR children it was inferred that the enzyme 5α-reductase is crucial for the development of the prostate and male external genitalia.
But what we see in clinical practice does suggest that 5α-reduction of testosterone is not obligatory for mediating androgenic effects in tissues in men. It has been seen that people who are 5AR deficient do continue to bald.
So the commonly held theory that testosterone needs to be converted to DHT has loop holes. It can be logically inferred that testosterone and DHT can both exert androgenic effects in all androgen-sensitive tissues. That their relative effects in any tissue are contingent upon their relative concentrations and potency.
------------------------------------------------------------------------
Know the World's TOP 20 hair transplant surgeons:
_______________________
Check these VIDEOS out as well:
CARE AFTER HAIR TRANSPLANT FOR FULL RECOVERY:
COST OF HAIR TRANSPLANT:
SEXUAL SIDE EFFECTS:
WHEY PROTEIN & HAIR LOSS:
SAW PALMETTO & HAIR TRANSPLANT:
SHARRY MANN HAIR TRANSPLANT-
WHY CROWN / VERTEX HAIR TRANSPLANT FAILS:
SAFE PROTOCOLS FOR BODY HAIR TRANSPLANT:
_____________________
OUR CLINIC (SAFETY FIRST):
_______________________
FOLLOW ME!
Come and follow me on...
________________________
COMMENT | SHARE | SUBSCRIBE
This is Dr Bhatti's Darling Buds Clinic. Our YouTube channel is a destination for those researching Hair Transplant and other remedies for hair loss. We make videos to showcase our hair transplant results on the web through YouTube; all techniques available for hair transplant; and advances in the field of hair transplant are often dealt with.
________________________
PRODUCTION CREDITS
All videos are shot, edited and uploaded by the Darling Buds Team
________________________
________________________
Call or whatsapp us at: +919814531111
#testosterone #baldness #DHT
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