Pyruvate Dehydrogenase Complex (2021) Drew Berry wehi.tv

Connecting Glycolysis with the Citric Acid Cycle and the Electron Transport Chain.

[bumpstockbilly]

please continue to make these videos, they are fascinating, informative, entertaining and bizarrely soothing

thank you so much

[yakarotsennin]

Just in time for my exam on Metabolism and Respiration! Appreciate the beautiful, yet highly detailed animations.

[chickennuggetscoon]

Life is infinitely complex. And the humans that figured these things out... Wow. Amazing

[lordofthecats]

Sweet! New WEHI animation just dropped! =D

Do you have a blog post or video on your process of making these animations? Seeing the different production steps would be super cool and informative for biochems & animators alike. I'm particularly interested in how you got hundreds of protein instances to wiggle, rotate, change states, and collide without needing a supercomputer. Obviously you're doing something to make it faster (and awesomer) than typical MD sims.

[sakubashiba]

this explains allot....thanks for this guys...

[rb]

Please explain how the structure of these flexible complexes was determined. You can’t X-ray diffract moving arms in a gooey environment.

[mahdimikaeeli]

Awesome! I love em. They're just so real

[glenliesegang]

"Complexification" is my made up word to mean a protein starts as one simple one and new ones appear which not only mesh properly with the old one despite unique encoding, but actually enhance it.
When it comes to the initial first ribosome of one simple protein plus some RNA, i do not see a means by which multiple a.a. strands "just appear, " which work as a group to produce a more effective one.

[danielhicks]

Is the pyruvate transporter really just wide open like that all the time? Surely there is more than just size gating at play?

[rb]

No wonder people believe in Gods. Any one system is so complex it is unfathomable. Chemistry and physics does not help understand. These are another level of complexity. Simulations help…

[joaquinfogel]

Love the videos, but please add music or something, the oddly squishy/rustling sounds make me uncomfortable lol