Endocrinology - Calcium and Phosphate Regulation

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[MelbourneMaster]

If you're looking for a few extra steps and more in-dept:
The precursers of vit D comes from foods (like oily fish; D3), plants (D2) and the sun D3. In the skin the suns UV-rays converts 7-dehydrocholesterol into cholecalciferol D3 (done non-enzymatically by heat). Cholecalciferol then moves into the liver (transported from the skin by vitamin D-binding-protein (DBP), and by cholemicrons from the diet) for the first part of its activation. Here it is converted by the enzyme (cytochrome P-450–based enzyme) into 25-hydroxy vit D3 (25-OH-D) (calcidiol) the step is called 25-hydroxylation, it then moves to the kidney for its second and last activation. Here the 25-OH-D/DBP complex is taken up at the surface by renal proximal cells by a specific mechanism involving cell surface receptors; megalin and cubulin. In the kidney 25-OH-D is converted to 1, 25 dihydroxy vit D (1, 25-(OH)2D) (calcitriol) by renal-1α-hydroxylase - this activation is called 1α-hydroxylation (patients with renal failure therefore cannot perform this step). The 1α-hydroxylase comprises 3 proteins: Cyt P-450, a ferredoxin and a ferredoxin reductase for activity. 1α-hydroxylase is strongly downregulated by 1, 25-(OH)2D (calcitriol) and strongly upregulated by PTH as a calcium homeostatic loop.

[aboutmedicine]

I think its worth mentioning phosphate doesn't need Vitamin D for uptake from the diet. This is part of the reason why in chronic kidney disease, you have low serum calcium but high serum phosphate. The kidney can't make Vitamin D if its diseased, so calcium uptake is not enough, but phosphate can still get across from the intestines into the blood. Cheers Armando you rock by the way : )

[KeirDickson]

This video just taught me more in 11 minutes than my lecturer has in like 235 powerpoint slides ur the best

[adnanbashi]

You forgot to mention that PTH reduces the reabsorption of phosphate from the proximal tubule of the kidney, which means more phosphate is excreted through the urine!

[zeynepecearslan]

what would i do in med school without your videos

[Partycornchips]

I just love this guys handwriting. It's so regular and consistent.

[Nina_]

this is truly an amazing explanation in a short amount of time compared to long complicated lectures ! thank you so much sir

[panashechitsike]

you are such a lifesaver. this was so clear. cleared a lot of confusion I had on the main hormone that controls bone growth and remodeling. keep up the great work! looking forward to more of your work.

[chrisland]

I'm studying this stuff and it's great to see it in easy to see pictures and descriptions/words. And you have pretty impressive hand skills!

[FlyingPiesOmg]

your endocrinology videos are second to none, great job!

[langeo.]

when he is more of an artist and a scientist combined in one human entity... Respect Boss...

[Unknown-ftwz]

1 to 2 hours lecture in just 11 minutes...
Thanx a lot....🥰

[__h]

videos like this in youtube became my teachers in online class.. I shouldn't enroll in school 😂.. I should enroll in youtube😂

[dominiquelee]

You have a gift of teaching! Your videos are so clear and easy to comprehend! THANK

[sarasultana]

You've got some wonderful content in here!!! I discovered this channel a few weeks ago and my whole study game has changed ever since! Thank you so much @armandohasudungan

[fiza]

Honestly thought this was animated till looking closer, props to ur drawings and hard work

[محمودجمال-بت]

Brief, clear, and knowledgeable.
Keep up the good work.

[himanshusisodiya]

I just cant tell how happy i m to find ur channel

[angelarebelo]

i had an eyegasm while watching this, also your accent is so good!! tysm for this, i search everywhere for a good video about calcium homeostasis and here i am. tysm for explaining it this way. also, the drawings, i loved them!! thank you thank you

[johndytiapco]

OH MY GOD, I LOVE YOU DUDE, U MADE THIS CONCEPT SO EASY TO LEARN