Insulin Secretion

The pancreatic cell in a resting state (fasting blood glucose) is hyperpolarized. Glucose, entering via GLUT transporters (primarily GLUT1 in humans, GLUT2 in rodents), is metabolized and elevates cellular ATP, which inhibits. K+ entry through the KATP channel; the decreased K+ conductance results in depolarization, leading to Ca2+- dependent exocytosis of stored insulin. The KATP channel, actually a hetero-octamer composed of SUR1 and Kir 6.2 subunits, is the site of action of several classes of drugs: ATP binds to and inhibits Kir 6.2; sulfonylureas and meglitinides bind to and inhibit SUR1; all 3 agents thereby promote insulin secretion. Diazoxide and ADP-Mg2+ (low ATP) bind to and activate SUR1, thereby inhibiting insulin secretion. Incretins enhance insulin secretion.

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[roosnijhof]

I don't understand how more Potassium in the cell, which is postitive, will lead to more calcium in the cell. Calcium is also positive, woudn't this lead to more depolarisation? I would expect something negative, like hydroxide to enter the cell. Why isn't this the case?

[lucilaalvarez]

Wow that was beautiful..i cant believe im using that word to describe this anything in biochem..but ur depiction is nothing short of brilliant. Thank u 🙏

[shivammalhotra]

Excellent. Thanks for simplifying it so much

[addicted]

AMAZING JOB!!! Explained so well THANKYOU

[mtu_ne]

giảm phân cực dễ xuất hiện điện thế hoạt động hơn

[abdulaziz.]

Good work, enjoyed your work very much.

[nachiketpargaonkar]

How does blocking K+ efflux lead to lowering of intracellular K+? & How does that lead to depolarisation?

[hiparesh]

superb... Thanx for sharing info... 👌👍

[bijouninou]

glucose -> glucose 6p with Atp->ADP it meansADP incrase and atp deacrease i need ansewr please