Ran GTPase Cycle and Nuclear Transport | Importins and Exportins

Lesson on the Ran GTPase Cycle and the mechanism of Nuclear Transport involving importins and exportins. The Ran GTPase cycle is critically important for nuclear transportation of transcription factors and other proteins into and out of the nucleus. The RanGTPase cycle induces a Ran gradient, which leads to increased levels of RanGDP in the cytosol and RanGTP in the nucleus. Importins and their cargo, along with RanGDP enter the nucleus through nuclear pore complexes. Once inside the nucleus, RanGDP gets processed to RanGTP.

Hey everyone. In this lesson you will be introduced to the Ran GTPase cycle, what it is and why it is important. You will also learn about how proteins such as transcription factors can enter and exit the nucleus with the help of proteins known as importins and exportins, respectively.

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Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

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*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*

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JJ

[nasserk]

Great video! But correction, the "RCC1" protein known as GEF does not add a phosphate to the GDP. It trades the Ran-GDP for a Ran-GTP

[Chris]

Thank you very much an excellent video! Im from Germany and study medicine and your video was very simple to understand. There is just one thing i`d like to say, in the nucleus the Ran-GDP is not made to Ran-GTP by adding anorganic phosphate, the enzyme replaces the GDP by GTP.


Greetings from Germany!

[catherinefauteux]

you just saved me 3 hours of studying. I love you xxx

[Juligonza]

This is the most beautiful video I have ever seen. You made a very difficult concept very understandable.

[manyakonkalmatt]

I've been trying to figure this out for days but this video was very understandable. Other videos have made sense of the process, but still left me with a loose understanding of the process. This is the only video that made me understand it. So lucky this wasn't on my quiz yesterday lol.

[jeanettequintero]

You just explained such a complex process in the most simplest way and I am forever thankful I found this very IMPORTIN video

[maelstrom]

That was awesome. Thank you so much. I was having a horrific time with the slide handed out. Your video made it crystal clear in just a few minutes!

[theprodigalbum]

Thanks for the concise explanation. This is way more useful than a prof pointing at a still picture in a lecture.
Look forward to seeing other videos you've put together.

[Evelinadav]

bless your soul, saving my life in prep for molecular cell biology final exam in med school

[Philip]

Thank you so much for explaining nuclear import and export! The microbiology textbook over complicates these pathways! You literally took a concept that took my professor at least an hour to explain into 7 minutes lol. Thank you again!!!

[_anjali_]

Really so helpful thank you so much for this video 😭❤

[tomass]

This channel deserves way more subs! Thanks for your effort :D

[belovedestate]

Thank you, this thoroughly explained both processes step by step and clarified some previous diagrams I had visited

[altayersat]

The video is so easy to understand. Thank you :)

[shrutijeurkar]

its really Well explained with proper labelled diagrams

[aminahafsi]

Thanks for the explanation💙..you really saved me😌

[melaniecragan]

You rock!!! Thanks so much and do I sense a Canadian accent?? I love it

[melissarainchild]

Super, I can further my studies now. Thank you...

[veraterbraak]

thank you so much! It was a great video and it helped me a lot

[grantbarnes]

This my favorite video on this, thanks. But can you upload a higher quality, because I can’t read the labels on my phone?