Introduction to Antirheumatics (DMARDs)

Rheumatoid arthritis is an autoimmune disease that primarily attacks the lining of the joints. While we are familiar with NSAIDs for their anti-inflammatory properties, with RA a much more useful class of drugs is DMARDs, or disease-modifying antirheumatic drugs. These can be of two varieties, small molecule, and biologic. What are the differences between these classes, and how do they operate? Let's take a look!

Script by Chris Hofmann

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[SirbelWasTaken]

I've started getting you reccomened after watching flat world videos and now I'm a consistent watcher!

[drunkserval]

Been fighting RA for 18 years now, thanks for this easy breakdown.

[DerrickMugambiM]

Great content. I am a Pharmacist from Kenya and I like the way you integrate pathophysiology, medicinal chemistry, pharmacology and pharmacognosy all into one simple video

[shakagod]

Me too. Dave has a great ability to break down these topics clearly and quickly. Great stuff.

[santicruz]

Thanks professor! I feel a little more prepared for my pharmacology class for my next semester thanks to all your videos :D

[yuvrajjha]

Thanks for your unique biology explanation! Really looking forward for Astrophysics explanation. Hope you make a video to calculate Luminosity of a star.

[devalsinhsindha]

my respects professor if you are reading it
i just wanna suggest that you make content on 1 specific type of topic for a series of ep. and then change the topic. also you should keep thumbnail and title understandable, related to daily life, current trends at global level, and surprise the viewers making them feel knowledgeable. otherwise you are doing fabulous
And by the way i am your subscriber from last 1 year.
all the best

[qwaeszrdxtfcgvbqwaeszrdxtf]

I have a question.The orbitals of electrons are just their wave function right.Can they collapse when interacting in a certain way.If they do what causes them to collapse and what consequences this collapse have.

[Psychx_]

Methotrexate is such a potent immunosuppressive that long term therapy might also increase the risk of cancer. People who are given it against RA have to take an "antidote" 24 hrs later, as it completely wrecks the signaling and metabolism pathways associated with folic acid. My grandma had to take it once a week and those were always her difficult days. Side effects may include general signs of intoxication: Weakness, low blood pressure, sweating, nausea, feeling ill, vertigo, … These symptoms usually subside 24hrs after taking the antidote. Against RA it was very effective though.

[sanashabir]

intro animated part always makes me grin 😅😍

[ApostolosKatsioulas]

I don't have RA, at least for now. The rheumatologist that is following up on me believes that my reactive arthritis is showing signs of early to moderate either psoriatic arthritis or ankylosing spondylitis. I am taking 1/4 of a Medrol 16mg pill for now and tomorrow I'll have my 3rd weekly injection of methotrexate. Will I be taking methotrexate for the rest of my life if symptoms disappear and my blood tests don't indicate anything pathlogical? Thank you in advance.

[BlueJean]

Can you please post a video about hydroxychloroquine for RA?

[glennpearson]

Informative as always, Professor Dave. Quick question: What RA symptoms typically present to a physician that might suggest going straight to a bDMARDS regimen? Based on this video, it sounds like going to bDMARDS is a fool's errand unless there are some very specific problems.

[OceanAce]

Sinus infections are the most common side effect from those taking bDMARDs. Speaking from experience.

[Ohmloud]

Speaking of psoriasis, when the tubes of leo wher out of stock and stopt qpleing it, my spo whend away. Its like libbalm but more expensif.

[preciousmoreen]

You an expert in mathematics? I really need help

[balam]

Anyone else read the title as "Introduction to Antimemetics"?

[brianstockton]

I hope I get to meet you one day I really wanna fight you I hope you see this..lets make this happen Im willing to travel