The New Marker for Heart Disease that is BETTER than LDL Cholesterol

In this video I talk about Apolipoprotein B, a marker that has shown to be more effective than LDL cholesterol for predicting heart disease risk. I talk about what it is, why it is important, and how understanding the role of Apo B in heart disease can help you reduce your risk.

[Straightdeal]

Your simple explanation explains a lot. Each LDL has one Apo B protein, and there are other contributers as well, like VLDL and IDL.
What many people also don't know, is that the Apo B protein attached to the LDL particle, contains a key that allows it to be taken up by an LDL receptor. But if the LDL has become damaged (small, oxidized), the Apo B key also gets damaged, and cannot get taken up by an LDL receptor, and removed.
The irony here is that a person who takes statins, will remove large, healthy LDL particles from the system, and they pose no risk.
The small, dense LDL's cannot get taken up. So our "poison" as I like to call it, lowers LDL particles and thus LDL-C without lowering risk! And doctor and patient are smiling because LDL-C and total cholesterol have come down, yippee, risk has been reduced!
But as you rightly point out, the real villians are still in there, and an Apo B test would have revealed this. Apo B count would have been high.

[athomeandtravel]

Studying this like crazy. You explained it beautifully. Thanks

[maattie]

Best explanation of Apo B I have seen. Thank you.

[ukiahsguitarsolos]

Good video. I'm having a blood test soon and I requested 'Cardio IQ'' by Quest which is a particle number and size test. Hopefully, I'll be getting the same important information with that.

[delvikingjr]

Thank you for explaining it clearly. I just today received results and didn't know what apo-b meant . Now I do. 83 was my number . I think they want it lower .

[daveb]

So if I have a ApoB of does that mean? How many VLDL, IDL and LDL particles does that translate to? Would it mean 70 particles per deciliter or something like that?

[bobcocampo]

Where can Doctors in the Philippines read what you said?

[erikjanse]

Thanks Dr. Adrian for this well explained VDO! So now what, if you are mdi-50's, have a healthy lifestyle (doing HIIT 3 times a week, doing resistance training 4 times a week, eating healthy non-processed foods, no alcohol or smoking, no stress and have wonderful sleeps. (BMI is 22, with low fat%, ie relative more muscle mass due to resistance training)) and have measured your APO-B and it turns out to be relatively on the high side, as well as having a CAC-score of around 150? What should be next steps to reduce one's risk of a heart attack? Thanks a lot!

[ernestocaamano]

Studies indicate that doctors are approximately 17 years behind/delayed the most current research. Saying that, Apo b testing may become a common blood test around year 2035.

[mikiemikie]

what type of blood test shows Apo B? NMR?

[vlatkopopovski]

Eight hours, or rather less, from the last meal, in the bloodstream of a healthy individual there is mainly free fatty acids bound to albumin, HDL, (lb)LDL, a little VLDL, negligible IDL and traces of other lipoproteins and remnants. In really healthy people, HDL should contain up to 1-2% triglycerides or 15-30 times less than cholesterol. LDL contains about 5-6% triglycerides or 8-10 times less than cholesterol. Taking into account the fact that in the bloodstream and in a healthy fasting person there is little of the other lipoproteins, mine and the results of other on ketogenic diets, I estimated that the total blood cholesterol should be over 9 times higher than triglycerides, in percentage of mass or molar in mmol/L. As difference (and/or ratio) is greater, better is for health. Thus, the triglycerides have to be below 0.6 mmol/L (50 mg/dL). This, you will not find anywhere else now, except in my book "The First Bioregulation" in Macedonian language.
ISBN 978-608-66828-0-4
Vlatko Popovski - Vladek
Skopje
North Macedonia

[shyjugovindan]

What should be the ideal value
I have apo A - 140
Apo B 160
Am i in the high risky category?

[chaseyaun]

Anyway to lower APO naturally ? I heard you mention lower carb higher fat. Is that a general recommendation I haven’t found much online aside from plant based, which I can try.

[ellfra]

So wouldn’t the size of the particles be a function of TotalLDL/Apo B ?

[haimeliyahu]

Great video, thanks for sharing!

One question though, what if the APO B is high (over 120 mg/dL) and the LDL Pattern is A? Does that also introduce risk?

I'm asking this question since based on available information, LDL Pattern plays a major role determine the risk factor. If the LDL Pattern is A ('big and fluffy'), the LDL will not go into the epithelial wall/ create plaquing. So why would APO B be used as risk factor in that case?

Thank you.

[MortgagePlannerTom]

Is your LDL particle # the same thing as your apoB #?

[andrewrivera]

It’s not about proteins, it’s about chronic high insulin due to excessive sugar/carbohydrate intake over the years. If you’re over 50 you should be eating a ketogenic diet with lots of leafy green veges. Macros: 60-70% fat, 20% protein and 10% healthy carbs and no corn oils. Intermittent fasting will further lower insulin and improve insulin sensitivity and throw in some block fasting during the year. Everyone needs to be cycling in and out of ketosis during the course of the year for optimal health.