Distribution & Factors affecting distribution of drug in body (Pharmacokinetics Part 4) | Dr. Shikha

Distribution & Factors affecting distribution of drug in body (Pharmacokinetics Part 4) by Dr. Shikha Parmar

Pharmacokinetics is currently defined as the study of the time course of drug absorption, distribution, metabolism, and excretion. Clinical pharmacokinetics is the application of pharmacokinetic principles to the safe and effective therapeutic management of drugs in an
individual patient. Pharmacokinetics influences the decided route of administration for a specific medication, the amount and frequency of each dose and its dosing intervals.

Pharmacokinetics of a drug depends on patient-related factors as well as on the drug’s chemical properties. Some patient-related factors (eg, renal function, genetic makeup, sex, age) can be used to predict the pharmacokinetic parameters in populations. For example, the half-life of some drugs, especially those that require both metabolism and excretion, may be remarkably long in the elderly

In pharmacology (and more specifically pharmacokinetics), absorption is the movement of a drug from the site of administration to the bloodstream.

Absorption involves several phases. First, the drug needs to be introduced via some route of administration (oral, topical-dermal, etc.) and in a specific dosage form such as a tablet, capsule, solution and so on. Drug absorption is determined by the drug’s physicochemical properties, formulation, and route of administration. The drug distribution is usually varied and depends on several factors such as:

(1) Blood perfusion
(2) Tissue binding (since drug binding is linked to the lipid content)
(3) Regional pH
(4) Cell membrane permeability

Pharmacokinetic- “What does BODY 1 do to the DRUG 2” we have simple interchanged the BODY and DRUG to make a definition. And as per the definition, our body responds to any drug by giving ADME effects.

1. A Stands for - Absorption
2. D stands for - Distribution
3. M stands for - Metabolism
4. E stands for- Elimination

Description Source: Wikipedia

[ankanbiswas]

Mam, i have a q, the physilogical ph of the plasma is 7.4, now the drugs which are absorbed in plasma are weak acid or weak basic drug, so they either have pk less than or greater than 7, , so in physilogical ph they should behave like ionized drug .... How they remain lipid soluble so !!?

[indhu]

Mam can I know the source of this informations