Coronavirus COVID-19 | Viral Structure & Pathogenesis

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Welcome to this video on the COVID-19 disease caused by the SARS-CoV-2 coronavirus. In this tutorial we will discuss:

- Structure of the SARS-CoV-2 virus and its structural glycoproteins
- ACE-2 receptor interaction and mechanisms of host cell entry
- Pathogenesis and mechanism of ARDS
- Typical chest radiograph and CT appearances

We hope you have found this video informative - see references below for further reading.

Peter & Jack

References used in the making of this video:

1. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 2020 Feb 15;395(10223):497–506.
2. Schoeman D, Fielding BC. Coronavirus envelope protein: current knowledge. Virol J. 2019 May 27;16(1):69.
3. Weiss SR, Navas-Martin S. Coronavirus Pathogenesis and the Emerging Pathogen Severe Acute Respiratory Syndrome Coronavirus. Microbiol Mol Biol Rev. 2005 Dec;69(4):635–64.
4. Lin L, Lu L, Cao W, Li T. Hypothesis for potential pathogenesis of SARS-CoV-2 infection–a review of immune changes in patients with viral pneumonia. Emerg Microbes Infect. 2020 Jan 1;9(1):727–32.
5. Frieman M, Baric R. Mechanisms of Severe Acute Respiratory Syndrome Pathogenesis and Innate Immunomodulation. Microbiol Mol Biol Rev. 2008 Dec 1;72(4):672–85.
7. Rabi FA, Al Zoubi MS, Kasasbeh GA, Salameh DM, Al-Nasser AD. SARS-CoV-2 and Coronavirus Disease 2019: What We Know So Far. Pathogens. 2020 Mar;9(3):231.
9. Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. 2020 Feb 26;102433.
10. Guo Y-R, Cao Q-D, Hong Z-S, Tan Y-Y, Chen S-D, Jin H-J, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak – an update on the status. Mil Med Res. 2020 Mar 13;7(1):11.
11. Jin Y, Yang H, Ji W, Wu W, Chen S, Zhang W, et al. Virology, Epidemiology, Pathogenesis, and Control of COVID-19. Viruses. 2020 Apr;12(4):372.

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Best video i've seen so far on the detailed structure. Still just scratching the surface. Thanks!

VVargames

perfect video, this should have a billion views

tomsmith

Thanks for this video... As a 4th year medical student... This has enlightened me more on why inflammation is the outcome of most diseases. And how inflammation destroys, rather than build.

muokamedicals

Thanks so much for this video! It's good to inform people about the pathology and clinical effects. Let's spread the word!

doornroosjevideos

I liked your video very much, you explain much better than many teachers I know, you are very clear and straight to the point.

dairamorales

That was very well explained and equally terrifying. This virus by its erratic nature and often asympomatic transmission has succeeded in halting almost all human economic activity within a very short time period.

briangriffiths

i'm sharing this, spread the knowledge (not the virus)

vergelab

I would like to say this video and the professor explanation is more than perfect. I am a doctor and I’d like to add my story here. I had all this mechanism and at the end I got ARDS(chest pain and difficulty in breathing) and I was on vent and inotropes. All my chest X-ray was like white clouds, I got Covid-19 with the first sign and symptoms are abdominal pain, tenderness in abdomen, loss of appetite, vomit and then severe headache with high grade fever, PLZ note: many doctors confuse it with acute appendicitis and it’s clinical picture is like that but actually no because in Acute appendicitis there’s no high grade fever like 103 F• or 104F•c most important thing you should know there’ll be itchy viral rash and some doctors miss it with drug reaction but actually it’s typical Presentation of Covid and maybe you’ll also get hand and foot syndrome. Severity goes on and I got ARDS( difficult in breathing) then I was on vent and some positive inotropes to get my normal BP. Thanks to God it took like one month in ICU to recovery fully but it’s steady. I wasn’t expecting that I’ll get second life but I’m grateful to my God, Doctors and all family members sincere prayers. One thing I want to add here it Covid is very different in everyone I even didn’t had any cough. So don’t wait for cough if you develop any sign do directly PCR and Covid SARS -2 antibodies test. Most important is supportive care and to maintain oxygen saturation, BP and some main vitals and low the D-Dimers etc . The rest of imbalances will get recover soon as some antiviral drugs recommended by WHO which weakens or break the proteins of the virus. This is my own story and now I’m like normal person got recovered totally so no worries be strong and everything will be fine.

wildlifenatural

Oh God we need your mercy 🙏 for us how it is hard especially for people who have chronic illnesses? like heart, lung and breathing problems. It will completely shut the system down from top to bottom please our lord we need you.You are our hope nobody couldn't do anything with out you please give us your mercy 🤔😱😵

Nazry

Finally found a great video that explains in-depth info on this!

sour_krause

This video pretty much covers everything about the virus. Thanks for sharing.

SChome

Thanks for sharing the most complicated subject in a simpler form, truely its a great video, with clear and detailed explanations. thank you so much . its great for teaching . great artistic work helps us to understand the unseen molecular world based on technological science and research advancements . aplause to the TEAM.

ylsb

Brilliant brilliant brilliant video

Simple clear and informative

ZubairKhan-vsfe

Citadel of Void (CoV) is a cancelled, [i][4][5] NilIcon nil difficulty, mixed-progression-based Citadel that was to be located in Emblem Ring1 Ring 1.[6] CoV is a well-known nil difficulty citadel, [b] with a 10-floor ascension section, 4-floor sideways progression, and concluding with an 8-floor descension section. The current version of CoV can be played in its own place here, and the original Tower of Void can be played here.[j]

CoV is no longer found in Ring 1, although rarely in the ring select it may appear (please note that despite it rarely appearing in the ring select, it is not available in-game). It was originally meant to be found via solving a series of complex puzzles across The Great Inferno, which required logic and critical thinking skills.[7] The current difficulty range of this citadel's floors ranges from Challenging to nil.[k]

This citadel was later split into two halves, nerfed, and added to Pit of Misery as Tower of Eternal Void (Only F1-10 and nerfed to be HorrificIconModified100 Horrific), [l] and Citadel of Infinite Void (Floor 11 onwards, nerfed to UnrealIconModified100 Unreal).

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