What Pathological Changes May Cause the Symptoms of Long COVID?

November 1, 2022
Bateman Horne Center has partnered with the University of Utah Health to conduct a Long COVID and Post-Viral Syndromes ECHO (Project ECHO). This series delivers information to healthcare professionals utilizing short didactics and case-based learning to enhance their ability to manage patients with long COVID, ME/CFS, FM, and related comorbid conditions.

Anthony Komaroff, MD, Simcox-Clifford Higby Professor of Medicine, Harvard Medical School and Senior Physician at Brigham and Women's Hospital discusses:
- How the symptoms of long COVID are shared with other post-infectious syndromes
- The underlying pathophysiological changes in long COVID
- The possible triggers of long COVID, including reactivation of latent viruses
- How the underlying pathophysiology of long COVID causes its symptoms

Note to community members: We advise viewers to always speak with their medical care team prior to making any adjustments or changes to their current regimen.

Bateman Horne Center’s involvement in this program is made possible with the additional support of the Open Medicine Foundation.

[BJ-bcsl]

Finally a doctor that speaks logically, with scientific thought and doesn’t gas light these poor patients struggling to recover.

[laurabone]

To his question on LDN: I am ME/CFS & Long Covid contracted pre vaccine. Yes I use LDN. Took just 8 weeks to normalize CRP levels. Important to me it addressed brain fog. Almost eliminated daily crash naps. Gives me insurance policy against cytokine storm if I get reinfected probably. For now will continue to use. It's so safe we don't need to wait for the pending studies. 60% improvement for me.

[kristen]

I actually got vaccine induced long Covid and am presently in an ongoing NIH study regarding the same. The symptoms are similar to CFS, except I got paralysis, vestibular equilibrium loss, etc. IVIg helps a little, antihistamines helped some, mostly pacing. But, if I get sick, complete rebound. Rather frustrating.

[janisedmondson]

I listened for treatment…I didn’t hear any. Still thankful for efforts of these people.

[marciemyers]

I had a low grade fever every day since CFS in 1994 for 20 years until taking Valcyte 450 BID continuously and no more fever since.other symptoms remain however. Marcie Myers

[rosemullen-rw]

So does injury from the shot! Wake up people!

[oibal]

TY. I never got Covid19, any variant. My heart goes out to those of you who got this evil infection.

[D-Fens_]

I wish I had a real doctor, mine just wanted to give me Paxlovid and antidepressants. I told him to piss off.

[Gina-dnxm]

I don't know if they will find treatment for ME/ CFS in my lifetime, but hopefully, someday in the future. It's like being in purgatory. you're not alive but not dying. You just exist mostly in a darkened room in bed.
I'm not Catholic, but I could think of a proper word description. 😊

[bradsalz]

There is a related compound called dextro-naltrexone. My understanding is that it is a sterioisomer of naltrexone which is active at microglia receptors (like ordinary naltrexone) but has no activity on opiod receptors. Because of this it is not limited to the same low doses that ordinary naltrexone is prescribed at making it an attractive alternative to LDN. Do you know of any research papers that discuss dextro-naltrexone?

[bluescrew]

Difficult to be vaccinated & double-boosted yet catch omicron in June of 2022 & have Long Covid for now over 1 year.

[decafmocha]

Thank you very much Dr. Komaroff. I have 2 goals : 1. To fine the best treatments for long covid. 2. To get in a clinical trial for long covid with the NIH. I think it is quite possible that I have had Post Long Covid Vaccination Syndrome for over 2 years now. It is very debilitating.

[GalacticTrveller]

I won the crappiest lottery, i had 2 vaccines and 2 boosters, and I'm dealing with long COVID :( not fun at all, and not fair either.

[LR-pxms]

I’ve been needing PT for herniated disc but I have also ME and been crashing with PEM. Are there any recommendations to hand out to physical therapists?

[JulieTobin-Ruszczyk]

An anti-inflammatory diet is the only thing that keeps my pain and fatigue low. LDN really didn't help me

[susantisdell]

Do you see more people with Blood Type A+ with long covid?

[leslievalenciano-lopez]

Does anyone else have long covid with brain fog, extreme fatigue, joint pain(fingers and pelvis), visual migraines and shortness of breath with no diagnostic tests to confirm long covid???

[thorinoakenshield]

Patients interest and willingness for studies is out of desperation for help and relief. We’ve already participated in the largest experiment of mankind.

[kellyschroeder]

Hmm. Trying anti inflammatory diet. My CRP ESR LDH IgA all elevated …..

[Michael-okg]

Long haulers symptoms are horrendous. It' is often lifelong. Fatigue pain depression and more. All are life altering symptoms