Considerations for creating knockout mice and other transgenic animal models.

Knockout mice are defined as having a certain gene of interest made inoperative, or "knocked out." Often referred to as KO mice, they are used to study gene function and to validate new drugs and treatments. Charles River delivers high-quality, validated knockout mice for generating consistent study data which makes research reproducible, and lowers overall study costs. Our end-to-end commitment ensures adherence of project timelines, confidentiality, exclusivity of intellectual property, breeding under VAF Plus® (SOPF) standards, and secure global delivery.