SSRIs reduce the effects of MDMA | taking prozac on your comedown | Benjamin Malcolm

This is a clip from 'Antidepressants and Psychedelics: Comparisons, Contrasts, and Combinations | Benjamin Malcolm, The Spirit Pharmacist', Adventures Through The Mind Podcast, episode 140

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[Profesah_]

Been on SSRIs for 20 years. High dosage. Never did any street drugs. Wanted badly to feel euphoria one time in my life. My friend gave me high amount of psilocybin and I felt nothing. I was very disappointed. But my SSRI blocks everything. I can’t feel any pleasure and it sucks. From watching this I guess MDMA won’t do anything for me either. I guess I have to wait until death until I get to escape this numb existence.

[Doors_of_janua]

Thanks to your channel I use this trick. Another guest once spoke about Prozac. I use it to block to withdrawal effects of MDMA in the days/week after using the medicine. I take half of a SSRI in the night before sleep the day after a session. Prozac is a dominant molecule that kicks the mdma out of the receptor. Mdma tends to stay for several days in the receptor and allows to leak serotonin for the next days until depleted. It does’t make the experience less beautiful or transformative and it does make the week easier. The trick is to take the SSRI before sleep so you don’t have this wierd day without highs or lows. Also other SSRI’s work well, you can use newer types. Can’t recall the names but there are better ones out there. Good luck stay safe!

[Billy-zs]

I'm on fluoxetine for 3 months i haven't done molly for over a year, yesterday i took 3 pills and i fell down and collapsed multiple times mast night and today i don't know if i should take fluoxetine today lr no, and also i have a really bad headache and when i stand up my blood pressure go down and everything turns black up to this moment i don't know what is happening to me and also if i keep my prozac normally or wait few days without it

[tesavek]

I tried 5 times, to expierence how mdma is like. I can’t remember if i quited the first time citolopram or the second time but first time i did mdma i felt nothing. Second time (if im correct i stopped citolopram for a week. (Can’t remember excatly anymore) but that time i felt alittle bit happy on mdma my friend said the is no way u almost feel nothing. Then months after taking citolopram again i took 3 times mdma bc i thought maybe i took from the wrong person i bought from 2 different people and they seemed to work on other people i felt absolutly nothing then i tried cristall form and my friend felt alot expierencing everything intense and i felt just a bit confident and relaxt thats all.

My question is is it really the citolopram that blocks the expierence why i’m not feeling antrhing. Btw all those 5 times i was on adhd medication aswell (ritalin).

Please could i get some advice. I can’t quit citolopram bc i get intensly depressed so idk i want to expierence mdma but seems like it doesnt work?

[NZealand]

I stopped taking my SSRI 5 months ago and I still can’t get the serotonin release on mdma. I’m praying my brain chemistry hasn’t permanently changed that I’ll never be able to roll.