Introduction to Human Leukocytic Antigen (HLA) for Transplantation Research - Dr. Nicholas Brown

An accessible crash course on Human Leukocytic Antigen (HLA) and relevant immunology background for transplantation research, aimed at students, staff, and faculty that are new to these topics. This lecture was prepared and presented by our lab's collaborator, Dr. Nicholas K. Brown, an Associate Professor of Clinical Pathology and Laboratory Medicine at the Perelman School of Medicine at the University of Pennsylvania.

We have edited and shared this video with permission from Dr. Brown.

Chapters:
0:00 Introduction
0:55 Cells of the Immune System
3:00 Adaptive Immune Cells
4:15 Adaptive Immunity
6:06 Example: SARS-CoV-2 Infection
7:56 Immune Response to Transplantation
8:47 Self vs. Non-Self Recognition
11:46 T-Cell Antigen Recognition
14:58 T-Cell Self vs. Non-Self Recognition
19:52 HLA and Self vs. Non-Self
22:35 Clinical HLA Testing
25:00 Transplantation and Self. vs. Non-Self
29:24 Cellular (T-Cell Mediated) Rejection
30:05 HLA Typing History
33:38 HLA Molecules
36:12 Genetic Structure of HLA
38:43 Molecular HLA Nomenclature
41:06 HLA Typing Resolution
42:35 Serologic Nomenclature
44:05 HLA Matching in Kidney Transplantation
47:24 HLA Typing Ambiguities
48:38 Imputation
51:10 Q&A