Unlocking immortality: the science of reversing aging

When it comes to human longevity, you might envision nanobots helping our bodies operate more efficiently. But our bodies are biological machines in their own right, evolved to handle any situation in the real world from illness to cold to hunger. Our bodies heal themselves, and they can be programmed to do so if we understood that language better.

This video talks about DNA and genes, and the epigenetic mechanisms that read that information. The epigenetic clock is one way to measure the age of cells, and this can be reversed with current technologies. We discuss experiments by David Sinclair, which made blind mice see again, and experiments by Greg Fahy, which regenerated the immune system of humans and reset their cellular age by 2 years.

Asking our bodies to heal themselves could be one of the largest medical breakthroughs ever, instead of trying mainly chemical means of medication. And it has significant implications for whether or not we can achieve longevity escape velocity and continue to live more or less indefinitely. This promises to be a very interesting topic.

#aging #longevity #science

The science of super longevity | Dr. Morgan Levine

Groundbreaking Research on Anti-Aging: Unlock the Secrets to Longevity | David Sinclair

Is Aging Reversible? A Scientific Look with David Sinclair | David Sinclair | TEDxBoston

Dr. Greg Fahy on advancing the first trial ever to reverse human ageing – Our Longevity Futures, with Chris Curwen | Ep. 2

Regenerating The Thymus: Profile Of Greg Fahy

0:00 Intro
0:21 Part 1: What is aging?
0:53 Demographics of immortality
1:25 Three paths to immortality
2:13 Observable effects of aging (side effect 1: telemere length)
2:45 Side effect 2: free radical damage
3:08 Side effect 3: unbalanced states
3:27 Side effect 4: epigenetic damage
3:50 Example: Sequoia trees live for centuries
4:20 Beneficial and negative mutations
5:52 Cells are untrustworthy
6:30 Part 2: Overview of epigenetics
6:41 Some history of DNA discovery
7:11 Explanation of how DNA encodes genes
8:28 Explanation of the epigenome
9:13 The effect that mutations will have
9:53 DNA methylation = epigenetic clock
10:49 Example: immortal jellyfish and transdifferentiation
11:42 Reprogramming our software
12:17 Part 3: Reversing the epigenetic clock
12:20 Research from Shinya Yamanaka: artificial stem cells
13:13 Research from David Sinclair: curing blindness in mice
14:19 Holy grail for treating diseases
14:42 Research from Greg Fahy: regenerating the immune system in humans
15:37 Regenerating the thymus
16:44 TRIIM trial, making humans 2.5 years younger
17:44 The path to immortality (advice? :))
18:49 How long we have to wait
19:03 Conclusion
19:50 Nature resets epigenetic clocks too
20:16 Outro

[DrWaku]

I was surprised at how much is out there on the topic of longevity medicine. It's very inspiring. Sorry for the 20+ minute video :)

Thanks to @ginxzypher, @vitzcar6219, @ProbingPolitics, and others for asking about longevity in my comments and inspiring this video. Keep it up. Cheers.

[BK-dyjk]

MY Mother had a stroke in her eye and is blind and to see her feel her way threw life is heart breaking and I would love nothing more than to be able to have her see again, just like the mouse model that was healed of blindness. It’s one thing to live longer, but without being able to hear or see or some other health problems You really do suffer.

[jverart]

Thank you so much for this video. I needed your take on this. I also watch David Sinclair clips and it's astonishing to see all that's been uncovered. He even says that in the long run it wouldn't be very complicated to distribute. Just insane. Looking forward to it! :)

[mjrare]

Great video like always ! This subject has interested me for several years and it's crazy to see the progress we've made! I think that in the decade 2030 we could already be immortal in theory :)

[Bellshazar]

My guess is that it will be sometime in the 2030's when real anti-aging therapies become available.

[alexyogaluz]

work by biologist Michael Levin...forgot to mention the promise of Regenerative Medicine through decoding the Bioelectrodynamic system of the human body.😊

[phen-themoogle]

This was so interesting that I watched the whole thing! Normally I have a horrible attention span issue and can only watch a few minutes of something but this was exciting! Very well made!
I especially enjoyed your line " you're encouraging your body to treat itself by playing piano on the epigenetics of your cells" around 18:40 to 18:50. As a former pianist that one really *struck a chord* with me xD
Do you have any videos on sound frequencies and are there really healing vibrations or how does music work with our bodies?
I once got rid of a persistent headache by listening to a reiki-chant cd with headphones when I was younger and I have no idea how that worked.
Sometimes certain cds felt like they reduced inflammation for me, but maybe it was also because they helped me focus on healing too...

[typhooni]

I was at Cambridge about a year and a half ago, and I saw that bar (The Eagle was the name of it, I think), and the plaque as well

[SmallSloth]

Thank you! This was a really fun video, I always love learning about cutting edge biology research - it always blows my mind. I would love for you to cover research done by Michael Levin, something like his xenobots or whatever you find most interesting

[susymay]

Is there a way to join a new TRIIM trial?

[roshni]

I always recommend your videos to everyone I know

[cammccauley]

Dr. Michael Levin’s work is pretty awesome too.

[ProbingPolitics]

Awesome! Thanks for covering the this, it's been such an interesting topic as of late. I would love to see what your thoughts are and what research says about the other two approaches to immortality (Digital uploads and nanobots)

[SilverFank]

Thanks for covering Longevity & Life Extension! You covered many topics and seemed to really do your research. Are you a fan of longevity?

[chrissscottt]

We live in interesting times. I'd be interested in a follow up video. Cheers.

[Pikminiman]

I definitely want to hear your takes on the other paths to immortality as well.

[motopaediatheview]

The philosophical analyze would be great, thanks.

[ethimself]

Just my take - More health related vids would be great. Just found your channel now. 👍 - 👍Rock on

[marcusiA-immortalistMarcus]

Forever on this amazing earth💪🏻 . I Love nad plus

[LeonvanBokhorst]

I had so much fun watching your great work again. It seems to me wonderful, though a tad mad science. I would be truly interested in a systems approach towards aging, as we're connected beings. 🙃