Pharmacology - DRUGS FOR HYPERLIPIDEMIA (MADE EASY)

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Lipid-lowering agents, or hypolipidemic agents, are a group of drugs that are used in the treatment of high levels of fats, such as triglycerides and cholesterol, in the blood. Hyperlipidemia (also known as high cholesterol) is the key contributing factors to the development of atherosclerosis (hardening of the arteries), which can lead to stroke and heart attack. This pharmacology lecture covers topics such as pathophysiology of hyperlipidemia; lipids, cholesterol, triglycerides, phospholipids, bile acids, fatty acids, lipoproteins, apolipoproteins, chylomicrons, VLDL, LDL, HDL, lipoprotein lipase, atherosclerosis, and vascular inflammation; mechanism of action of lipid-lowering drugs and their side effects; HMG-CoA reductase inhibitors (statins), nicotinic acid, fibrates, bile acid sequestrants, cholesterol absorption inhibitors, pcsk9 inhibitors, omega 3 fatty acids. Drugs mentioned include; Atorvastatin, Fluvastatin, Lovastatin, Pravastatin, Rosuvastatin, Simvastatin, Niacin, Fenofibrate, Gemfibrozil, Colesevelam, Colestipol, Cholestyramine, Ezetimibe, Evolocumab, Alirocumab, Docosahexaenoic acid (DHA), Eicosapentaenoic acid (EPA), Icosapent ethyl, and Fish oil.

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0:00 Pathophysiology of hyperlipidemia
4:18 HMG-CoA reductase inhibitors - Statins
6:20 Nicotinic acid - Niacin
7:39 Fibrates
9:25 Bile acid sequestrants
10:51 Cholesterol absorption inhibitors
12:24 PCSK9 inhibitors
13:27 Omega−3 fatty acids

[SpeedPharmacology]

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[dunndenndonndinn]

Just wanted to drop a mnemonic for niacin (Vitamin B3)
- B3 stands for: "Beet" red (flushing), Big toe (hyperuricemia and gout), Blubber (acts on adipocytes)
- Also "NIce Try" = NIacin liberates FFA from TRYglycerides.

Also shout out to Speed. This is by far the best lipid lowering video out there.

[Yousafzaikamran]

being 3 year of medical school speed pharmacology have been best pharmacological Lectures ever they way you explained is phenomenal Apricate your hard work

[aadriohno]

I'm studying dentistry and this is extremely helpful for learning patients' medications which aren't taught well in school. I really appreciate your work, please keep up the great job.

[prashanthraju]

7:15 to minimise the side effect flushing. We can use aspirin concomitantly with niacin. Because asprin is a prostaglandin inhibitor.

[ZadeBatarseh]

Thank you! 2hr lecture in class summed up 1000x better in less than 15 min!

[jonathanrankin]

HDL = H for Healthy
LDL = L for Lethal

Obviously this is just to remember which lipoproteins are good for you and which ones are bad for you and H and L doesnt actually stand for Healthy and Lethal respectively

[onestopmusic]

We studied this lecture in class and it just went above my head but thankfully this video lecture saved my life <3 thank youuu

[minadz]

this came just in time. . i have a pharmacology exam tomorrow and this video saved me so much time. . thanks a lot!

[lamz]

I will name my child after your channel

[shellylynn]

Your videos are so clear, straight forward, and thorough! Thank you! Please make more!

[anthonyneira]

Perhaps, the best video I have seen about antihyperlipidemic medications! Thank you!

[AnjaliKumari-btgo]

This is so amazing so handy in short perfect to the point explanations. The effort is fully appreciated, Sir. Thanks.

[abeenfatima]

Explained in accordance with Lippincot Pharmacology.... Excellent job!
Found this really helpful ☺

[nicholaslem]

Thank you so much...You are amazing...I really love your videos...You really make things easier to understand....Thanks to you i got an A this semester...Thanks man

[globuspallidus]

you helped me a lot, really... may god bless you

[muneebmohammed]

I saw this video for a test today, and I did fairly good. Forgot the statin drug with 19hr half-life, and the drug interactions of Bile-binding resins though.

Thank you for your hard work.

[sandhyasingh]

Tu boht mast kaam karta hai speed pharmacology bhai

[eulllight]

Y would someone dislike this!!
Thanks alot

[nightbot]

I just see full 3min advertisement for you bro,
Please keep it up