David Sinclair on the Brink of Anti-Aging: Reprogramming Cells for Eternal Youth

In this episode of the James Altucher Show, James dives into a fascinating conversation with Dr. David Sinclair about the groundbreaking research on aging and potential ways to reverse it. They discuss the intriguing concept of using low-dose medications for unexpected benefits, the discovery of DNA by Francis Crick and Jim Watson, and Sinclair's paper on the information theory of aging. The discussion covers the difference between genetic and epigenetic information, the possibility of reversing aging by maintaining or restoring the information contained in our DNA, and the remarkable evidence from animal cloning that supports Sinclair's theories. They also explore the current challenges and future possibilities of gene therapies for age reversal, including the reprogramming of cells using Yamanaka factors, the experimental use of specific chemicals to rejuvenate cells, and the potential implications of testosterone and other supplements on aging. Sinclair's pursuit of understanding the epigenome and its role in aging, alongside the practical application of this research in treating conditions like blindness and extending lifespan, provides a tantalizing glimpse into a future where age reversal could become a reality.

00:00 Exploring the Unusual Uses of Viagra
00:12 Introducing the James Altucher Show
00:24 The Fascinating World of DNA Discoveries
00:46 Unlocking the Secrets of Aging and DNA
01:46 The Revolutionary Concept of Age Reversal
02:21 The Potential of Epigenetics in Reversing Aging
05:36 Exploring the Possibilities of Age Reversal and Genetic Therapy
05:55 Navigating the Complexities of Gene Therapy and Regulatory Challenges
08:21 The Future of Aging: Supplements and Scientific Debates
12:17 The Cutting-Edge of Age Reversal Research
18:55 The Intricacies of the Epigenome and Age Reversal
24:34 The Promising Horizon of Gene Editing and Age Reversal
28:56 Exploring the Future of Viral Gene Therapy
29:08 The On/Off Switch for Viral Therapy and Its Potential
30:13 Understanding Aging and Cellular Reprogramming
33:18 The Brain's Learning Capacity and Aging
35:35 Reversing Aging: From Theory to Practice
43:32 The Path to Human Trials and Regulatory Approval
47:33 Exploring Off-Label Uses and Future Applications
49:32 Testosterone, Aging, and Other Health Insights

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[karl]

The most incredible thing is that we are not that far away from reprogramming our cells, and he 's proved it. He's at the cusp of maybe restoring sight to human beings, what an incredible feat. My biggest fear is that there are many people out there who will do whatever they can to jeopardise his work, not because they can do better but out of simple spiteful jealousy! Remember every single human being on this planet will get old one day and suffer everything that goes with it, if we can do something to negate that outcome not only do we profit but all the generations to come. It is far better to prevent these illnesses happening rather than treating them with dangerous drugs, which profit nobody but the pharmaceutical industry.

[cgsonic]

I have been watching Dr. Sinclair for about 2 years now. Finally about 3 months ago I bought his book, "Lifespan" in Spanish, and gifted it to my dad (77 years old). He read almost the whole book and started talking about NMN. We started taking NMN about 3 weeks ago, since then I've felt more energetic and feel better, my dad is yet to report results (I think it is too soon though since he is taking only 150 mg). We started taking 150 mg but about 3 weeks ago, I doubled it to 300 mg last week and started giving my wife 150 mg (She has rheumatoid arthritis), since then she said she has felt less pain and less stiffness. Keep doing what you are doing Dr. Sinclair, at least in my family it seems to be working....

[the_best_of_times]

Love this. Your enthusiastic "when?" and "would you do it?" and wouldn't a lab in China be doing this already is a baser line of questioning you wouldn't normally find in most podcasts. Good on David for playing along and not hiding from these questions.

[AndyColeman-ej]

David Sinclair has been a very very great scientist and his team is exceptional and he is very right about the 3 and not 4 factors, so far they are very much on point as far age reversal goes

[BrittanyB.-toct]

Ok I've been following Dr David Sinclair since 2019 and have been taking NMN since then as well Today is the first podcast I've seen interviewing him since about 2021. As I'm watching this podcast now I swear the information I received stimulated something in me and my body had rushes of tingling sensations. It feels like age reversal or like a power up like in a video game. Maybe our cells understand us and can get excited too. Really I'm not kidding.

[pgc]

At 5:30 and he is just a small kid/student asking questions. I like that. He is still so young in his brain.

[christinaatkinson]

James I love your questions! David keep going, your enthusiasm for this work is fantastic.

[peterm]

Great news about clinical trials curing blindness in human eyes starting next year. They are already talking to the FDA and see no show stoppers. This time next year (May 2025) they could be calling for volunteers for the trial.
Hopefully once blind people see again the penny will drop and everyone will understand that age reversal is real and more research money will flood in so that we can all become young again as soon as possible

[tocitim]

David, don't stop...Do the miracle

[adamal-hilali]

Love this. James has ability to ask everything you want to know, brilliant

[DrJK-wmec]

David Sinclair has lost a little of his pixie dust because of a few missteps.

However, there is no denying he is pushing the Longevity space in a new direction…looking at Aging as a disease, the hypothesis that there is of a back-up copy in cells that could be used to reverse aging, and more.

I do hope Dr. Sinclair does stay focused on his research and keeps pushing the envelope on Longevity science!

[joeblow]

Great interview. Thank goodness the nmn protocol was held to a minimum

[pwnfour]

Fantastic interviewer. Asked exactly the questions I've had for a while

[dannyozuna]

Yes, I'm ready for the upgrade!

[ludovicgago]

That was one of best or even the best podcast with David. Besides the book a lot of info was shared here. One big word for both : Thanks . And, keep us posted 😇😜😜

[trayrene]

Two of my favorites in one room! So good! James you ask the question everyone else is thinking (would David take the OSK??) and I’ve been waiting for this moment since DS came into my conscious awareness! Thank you!

[keithmarshalldds]

Would red light therapy be helpful as viagra for endothelial health? I would think even more so due to its direct effect on mitochondrial function.

[pgc]

At 34:29 and yes mindset and brain are vary important.

[bmilk]

appreciated for the gorgeous Host and Dr David Sinclair

[Rose-vpsn]

This has been the most informative video thank you