BRCA mutation

This breast cancer lecture explains about the brca gene (brca1 and brca2 mechanism) mutation which leads to the development of breast cancer.
A BRCA mutation is a mutation in both of the genes BRCA1 and BRCA2. Detrimental mutations in these tumor suppressor genes produce a hereditary breast-ovarian melanoma syndrome in affected families. Mutations in BRCA1 and BRCA2 are distinctive, and breast cancer is relatively original, so these mutations consequently account for only five to ten percent of all breast cancer cases in women.

1000s of distinctive types of mutations in these genes have been recognized. Excessive-danger mutations, which disable an primary error-free DNA repair procedure (homology directed repair), tremendously develop the character's threat of setting up breast cancer, ovarian melanoma and specific different cancers. Why BRCA1 and BRCA2 mutations lead preferentially to cancers of the breast and ovary is not identified, but lack of BRCA1 function seems to result in non-useful x-chromosome inactivation. No longer all mutations are excessive-chance; some show up to be harmless editions. The cancer hazard related to any given mutation varies greatly and depends on the distinctive variety and area of the mutation and in all probability different person reasons.

Ladies with unsafe mutations in either BRCA1 or BRCA2 have risk of breast melanoma that is about five occasions the average chance, and a hazard of ovarian cancer that's about ten to thirty occasions common. BRCA1 mutations typically confer a higher danger of breast and ovarian melanoma in females than BRCA2 mutations. Having a high-threat mutation does no longer guarantee that the girl will increase any sort of cancer, or warranty that any melanoma that appears was once genuinely induced through the mutation, alternatively than every other element, like alcohol consumption.
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[twogunsblazin]

I rarely leave comments on videos, but this one helped me out tremendously! I gave a presentation on the causes of breast cancer today and the BCRA mutations were still a bit fuzzy in my mind for whatever reason. I watched your video an hour before just to brush up and it helped more than I could have imagined it would. The presentation was flawless! thank you! I will be watching more of your videos!

[ladyarcher]

"The guardian of cell cycle" what a great description.
Thank you, I somewhat understood the process before but your explanation and passion really helped to solidify my understanding.

[brookejones]

My family has just been diagnosed as having the BRCA2 mutation, I am a nurse so had some understanding but this will be very helpful in explaining it to them. Thank you!

[littlepallavi]

Nicely done, mister! Very clear, direct explanation. Thumbs up!

[merissang]

I have to say this video really helps in my assignment! Explanation is really clear! Well done!

[arrictineseatingshow]

This really helped me a lot! Thank you Mr. Shomu <3

[Squawkingalah]

Thank you so much for this wonderful presentation. I have the BRCA1 mutation myself (as do other members of my family). This is a fantastic presentation of some of the detail about how this gene works at cellular level and what can happen when it is faulty. I had ovarian cancer (actually, primary peritoneal cancer, which is very similar) in 2014, was successfully treated and am living to tell the tale! Tracy, Bathurst, Australia

[princessandbluemoon]

You have earned a new suscriber!! Greetings from Mexico

[naseema]

Really well explained. Great video thank you

[nouraalbahli]

Thank you so much, couldn't get better
Great video

[sabiner]

Very well explained! Thank you so much. Would it be possible to identify the wrong proteine to add it somehow with some kind of pill or food?

[marciaaskarzadeh]

Thank u so much !!! It is great video! It help to my presentation about breast cancer! Thank you!

[CenobiteBeldar]

I like his videos however the old ones have lens focusing issues. Updated videos would be nice so learning isn't disruptive.

[dancejoy]

Wonderful video, very helpful, thank you.

[dipankarkoley]

Dear Mr. Sumen Bhattacharyya,
it is a very good educative video. Please, do a tutorial in the context of PARP and BRCA activity in DNA repair; PARP inhibitor selectivity cancer and normal cells.
Thank you very much.

[julianafontana]

Wow what a video, this was explained so well. I found the mutations in BRCA the hardest topic to get my head around and this video really helped me, thanks!

[sajalmishra]

Sir ur videos are a boon to me
thank you
however I want to compliment for one more thing
u r looking very handSome in this video

[doriscastillo]

All the way from Republic of Ireland filipino. Many thanks

[gajananpanchal]

Ur explanation is superb. Please let me know what exactly mean wild BRCA

[sriram-eccb]

Sir Please upload neutralist hypothesis