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Degradation of Purine Nucleotides easy #purines #uricacid #biochemistry

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Let's explore the process of uric acid formation from purines:
1. Purine Catabolism:
- Purines are chemical compounds found in nucleic acids (DNA and RNA).
- When nucleic acids are ingested in the diet, they are broken down into nucleotides by various enzymes.
- Nucleotides are further converted to nucleosides (base + ribose or deoxyribose).
- Nucleosides are then hydrolyzed by enzymes like Purine Nucleoside Phosphorylase (PNP) to release the purine base and ribose-1-P.
- Notably, adenosine and deoxyadenosine are first converted to inosine by adenosine deaminase before being processed by PNP.
- The PNP products merge into xanthine through guanine deaminase and xanthine oxidase.
- Finally, xanthine is oxidized to uric acid by xanthine oxidase.
2. Clinical Significance:
- Hyperuricemia occurs when blood uric acid levels are elevated due to impaired excretion or overproduction of purines.
- High purine intake from foods like organ meats (liver), beef, fish, and alcohol can contribute to uric acid formation.
- Uric acid stones may form in the kidneys under certain conditions.
#purinecatabolismtrick #uricacidformationmadesimple #purinecatabolismtrickuricacidformationmadesimple #purinecatabolismtrickuricacidformationmadesimplevideo #uricacidformationmadesimpleand #purinecatabolismtrickuricacidformationmadesimpleandrew
1. Purine Catabolism:
- Purines are chemical compounds found in nucleic acids (DNA and RNA).
- When nucleic acids are ingested in the diet, they are broken down into nucleotides by various enzymes.
- Nucleotides are further converted to nucleosides (base + ribose or deoxyribose).
- Nucleosides are then hydrolyzed by enzymes like Purine Nucleoside Phosphorylase (PNP) to release the purine base and ribose-1-P.
- Notably, adenosine and deoxyadenosine are first converted to inosine by adenosine deaminase before being processed by PNP.
- The PNP products merge into xanthine through guanine deaminase and xanthine oxidase.
- Finally, xanthine is oxidized to uric acid by xanthine oxidase.
2. Clinical Significance:
- Hyperuricemia occurs when blood uric acid levels are elevated due to impaired excretion or overproduction of purines.
- High purine intake from foods like organ meats (liver), beef, fish, and alcohol can contribute to uric acid formation.
- Uric acid stones may form in the kidneys under certain conditions.
#purinecatabolismtrick #uricacidformationmadesimple #purinecatabolismtrickuricacidformationmadesimple #purinecatabolismtrickuricacidformationmadesimplevideo #uricacidformationmadesimpleand #purinecatabolismtrickuricacidformationmadesimpleandrew