039 - We need to talk about C-Reactive Protein (CRP)

C-Reactive Protein (CRP) is a sensitive marker of inflammation. I am presenting some new data on CRP elevations I see in chronic pain and fatigue conditions. - Jarred Younger

[youngerlab]

ERROR: The hs-CRP values I show in this video are in mg/L units (not mg/dL as I claimed). I will look over the videos and see if I need to remove them or reupload with notes added. For now, just note that all values I mention are actually mg/L, which is what you are most likely to see from your clinic or hospital anyway. Sorry for the mixup! - Jarred Younger

[lego]

As a severe ME/CFS patient, I have noticed the correlation of CRP and fatigue. I only get labs that show CRP levels every 3 months, but they're routinely high. The lowest it's been is 3.7, and the highest was >10. I'm mostly home-bound but I can do very short doctor visits, but when the level is >10, I am in constant pain (requiring NSAIDs and gabapentin) and extreme fatigue. Not able to do things for myself. I'm eager to find a way to control this, and keep my levels low. And I'm looking forward to next week's episode focusing on the ME/CFS charts.

[saaugie]

My CRP was in the high range up to 2020. Then, I started taking anti-inflammatory supplements. Since then, all my CRP test have been in the normal range. I am a Gulf War Veteran who has been diagnosed with numerous chronic illnesses. To include fibromyalia, CFS, IBS, insomnia, migraines, undiagnosed Illness, arthritis, asthma, acute and chronic sinusitis, rhinitis, and numerous neurological symptoms and conditions.

[scotthicks]

Finally did the test a couple of weeks ago. Also tried to get the ESR, but it had both an auto and non-auto version. My provider ordered the wrong one, auto, I think, so it got left off of my lab work. Will do next.

[agnetalindstrom]

Looking forward to check CRP at home 🎯👍🏼

[spocksdaughter]

Thank You! And wishing success for us all. From the UK

[soggymoggytravels]

Thank you for providing proof for what some others deny exist.

[leslietascoff]

THANK YOU! ❤ I’m so glad that you’re looking into this. I’ve noticed that I have a LOT of pain when my inflammation (CRP) is high but I haven’t noticed a change in fatigue. I have seen my CRP go down within a couple days after an infection starts to resolve. I think it would be great to have an at home CRP device. I have glucose and Uric Acid test kits.

[Nuggetsoffudge]

The only thing that has helped in my case is taking high doses of Benfotiamine (Vitamin B1). I needed to get above 500mcg with 2x B100 Complex, 6000mcg of B12, 800mg of Magnesium bisglycinate, 6000-10000iu Vitamin D, 720-1200mcg Vitamin K2, 3600mg Omega 3. There may be a need for some Zinc as my skin sometimes gets rashes on my feet. My gut feeling is there is a chronic deficiency in thiamine in so many people, and it definitely makes sense for soldiers as they have chronic stress.

[puppytommie]

schön hundert videos! Schade dass du so versteckt bist im " youtube -wald" weil deim videos sind so hilfreich .
Und auch ein angenehmes aspekt Deutschsprachig .( bin Niederlandisch).
So gründlich erklärt.
Und ich spure schon kleine verbesserung.
Hartnackig, aber ich kann jetzt sagen ob ess aussieht ich habe die Manuell meines lebem zurück.
Vielen dank !

[clairenaylor]

Yep... My old doc (RIP) used to track my progress using CRP. Always not quite where it should be lowest i recall was 3.5, usually 5/6, sometimes 10/11

Looking forward to next week Dr Younger, vand thank you for your continued work 💙🙏🏼💙

[brobinson]

@youngerlab I see the plant flavonoid Luteolin turned out to be a good anti inflammatory in the inflammation stage of acute Covid. It’s a big paper so I didn't read if it helps with Long Covid or not, but probably would help
Study name:
‘Inhibitory Effect of Luteolin on Spike S1 Glycoprotein-Induced Inflammation in THP-1 Cells via the ER Stress-Inducing Calcium/CHOP/MAPK Pathway’

[regina]

When I had pelvic inflammatory disease 18 years ago. It was at 50 for a year until the bacterial infection in the fallopian tubes cleared up. It was a very difficult time of my life. The doctors never told me what a CRP of 50 meant. It was a scary period.
I hope noone can relate nor needs this information. Just putting it out there.

[TheKernal_]

any reason why many with MECFS have normal CRP Numbers ( No Biomarkers at all)

[brendabrenner]

Interesed in home test, , tu, mecfs really needed ..hopeful🙏💞

[helenaf]

Everyone I know with severe and very severe ME/CFS has low CRP! I hope this will be reflected in the data. Pro inflammatory cytokines are alolso mostly low and decreased whereas antiinflammatory and immune suppressive cytokines are usually very high. Modulation of these cytokines with things like BCG vaccine (which leads to Th1 and pro inflammatory switch) helps many severe pwME/CFS

[headbangingidiot]

The title and thumbnail game is on point

[ninner]

I know it does with me. Stress, anything seems to set off mine. I appreciate what you are doing Jarred and although I think what I have been doing has helped cognitively, it most certainly is difficult.

[inspectorraycharles]

I'm 72 years old and I've been fibromyaliga diagnosed for at least 25 years. I've had a lot of blood tests over the years including many CRP tests and I don't believe I've ever had any values that were abnormal. One if the ways my doctor diagnosed my fibromyaliga was my CRP values were normal even when I was having acute fibromyaliga symptoms with pain and fatigue but my CRP values are usually normal.

[kristinae.]

Your videos are so clear and easy for us non-doctors to understand. Thank you!