TWiV 754: Tuesday two: SARS-CoV-2 and TLR2

TWiV discusses the finding that the envelope (E) protein of SARS-CoV-2 is sensed by toll-like receptor 2 on cells, leading to the production of inflammatory cytokines that cause damage to cells and tissues in COVID-19.

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Twitter: @profvrr

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– Who Am I? –

I’m Vincent Racaniello, Earth’s Virology Professor.

I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

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#microbe #viruses #coronavirus #pandemic
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[Viri_naturae]

1:03:45 "Lloviu" is not Spanish but Asturian. "Lloviu" means "rain", while rain in Spanish is "lluvia".

[jodi]

I love the weather bit you start your shows off with! Great touch! It's a chilly, cloudy 51*F (11*C) with 92% humidity here in Oakland, CA tonight. I love your show. Keep up the great work!

[janetaylor]

I love the weather👏👏in my family we always include the daily weather. Nice touch.👍

[viperkeeper]

CVS has the Binax Now tests for ~$24 for two tests

[rogerscottcathey]

Was waiting to hear you mention the pepsin receptors on the alveolar epithelium . . .

[henkvandergaast]

OK.. night time Gerringong here.. Its cool.

To the lady with "long vaccine" syndrome, I really feel for you. The thing is you can get that from a flu like disease as well. I was crook with that sort of thing for 7 weeks in 2016. Ive not really recovered and had to go to a cardio to get real help.

They are basically as baffled as well..

We all are different.. I havent stopped having vaccines tho. Life is difficult enough. I would hope your physician takes this into account with preparations for future medications and preventatives.

Twenty six tho.. I have known a person who has not come back from shingles (at age 24). I hope your future is far better.

[tomsteinberg]

~ 01:50:00 -- wheelbarrow as rain gauge: some calibration required. My guess on the mushrooms -- from your screen shot, genus Panaeolus, frequently fruiting on decomposing wood. There are apps, of course, you can narrow it down. Re the missing tags, something with packrat habits.

[juanhervas]

My hospital serve as a tertiary hospital of 1M population. Only one case of MIS-C case in a child and very few admissions for covid in kids with no fatalities. What's the point to start now a generalized vaccination in children without the security of safety for them? Can we have such safety in a trial with 2000 children? Come on please!!!! Don't insult intelligence!!!! This would be just criminal in my opinion. We never did anything like this before.

[justleif]

There are studies that show that post covid infection immunity is less broad and some of the new variants can reinfect whereas the vaccine still protects against them, clinically.

[cab]

Love the banter. Listening to this TWiV, it occurs to me that we (humans) are awE-fully made (physiologically).

[marieparker]

How have the Chinese vaccines performed in Chile?

[pawpawforhealth]

Previous work on E protein in SARS CoV 1 indicated that it impacts virulence

[luisfernando-mmjt]

Love all you do.. Including the weather

[RalfStephan]

Why don't the paper authors show co-precipitation of E with TLR2, which would be standard procedure?

[sarabear]

Lots of diffrent garden apps could help you. Take a photo of it they can tell you what it is.

[Heartlandohio]

Mike Dewine has an Ohio Lottery thing starting for adults who have gotten vaccinated a free college tuition for 4 years for students. One winner a week for 5 weeks . That should get people off the fence.😷

[marieparker]

The UK is continuing with AZ vaccine, but only for people over the age of 40.

[Bit-while_going]

It's amazing how much new terminology one must learn to just begin understanding one single virus. Isn't this terminology growing exponentially, just like a virus? Could it be a meme virus itself, and will it reduce the ability of those infected to eventually go back to speaking in a regular way after the pandemic is over?

[m.s.]

I don't have brains to process virology, so I only listen to the weather bit

[pawpawforhealth]

May I suggest that the Palestinian authority could choose vaccines over missiles.