filmov
tv
COVID-19 and the brain...and what you can do about it!
Показать описание
COVID-19 is an emerging, rapidly evolving situation. This includes our understanding of it's effects on the brain. However, a range of neurological effects have already been observed and many potential mechanisms have been hypothesised. Time will tell how frequently the novel coronavirus attacks the brain in COVID-19 patients and how severe the consequences will be. Additionally, we will not be able to quantify the potential long-term effects of the virus on the brain until years into the future.
Today I explore some of the potential mechanisms of damage to the nervous system by infection with SARS-CoV-2 that have been proposed so far, which can be broadly grouped into two categories - indirect and direct. We will see how parallels can be drawn between COVID-19 and many of our top chronic diseases, and how this might inform how we can combat these neurological effects in the event that we do become infected.
But remember, the only way to ensure we avoid most of these neurological effects remains avoiding the virus altogether.
I will also touch on some nutrients that I think are of particular importance in COVID-19. There is a lot to cover in this video and it has turned out to be quite long even with my best attempts to stick to just the essential stuff, so I have added timestamps to each section below for easy navigation. I have also referenced many of my past videos to back up my points, or this video would have gone on forever! The links to these past videos referenced with timestamps are also provided here if you would like to follow up further:
0:00 Introduction
Diet, brain diseases and motivation for healthy eating:
1:57 Neurological effects observed in previous coronavirus outbreaks
2:22 COVID-19 neurological SYMPTOMS
3:00 Outline of COVID-19 neurological effects
3:46 Indirect effects of the novel coronavirus on the brain:
- 3:58 Blood clotting and disruption to flow
- 4:53 Inflammation, immune system and the 'cytokine storm'
- 5:54 Intestinal microbiome and the gut-brain axis
6:51 Direct and mixed effects of the novel coronavirus on the brain
- 7:00 Retrograde axonal transport
- 7:30 Happy hypoxaemia neural hypothesis: brainstem invasion
- 9:16 Blood-brain barrier
- 9:58 ACE2 receptor
- 10:34 Direct invasion from the blood and neurotoxin ingress
- 11:47 Reduced ACE2 function
- 12:22 Loss of brain blood flow autoregulation
- 12:49 Systemic dysregulation of blood pressure
- 13:27 ACE2-mediated invasion of brain and loss of autonomic function
- 14:12 Invasion and replication in the brain and secondary effects
- 15:34 Post-infectious complications and auto-immunity
16:15 All pathological processes take place on a background of hypoxia
16:49 Mental health effects
18:07 So what do we do about it?
20:25 A case for WFPB diet and specific nutrients
22:54 Modifiable risk factors for severe COVID-19
23:24 Diet and modulation of the immune system
24:25 Intense inflammation, profound immune system priming and predisposition towards brain diseases
25:04 Nutrients that may be of particular importance in COVID-19
- 25:16 Vitamin D
- 26:04 Zinc
- 26:47 Selenium
- 27:46 N-acetylcysteine
My video on zinc:
29:55 The COVID-19 pandemic as an opportunity
31:02 SUMMARY
32:39 A final thought
33:31 Diet and brain health in general
33:54 References
Since this disease has only been with us for around a year and there is no way many of the hypothetical mechanisms of neurological effects can be validated and quantified yet, I have weighted this video towards a qualitative analysis of COVID-19 brain effects. I think it is too early to call how common neurological sequelae are going to be - they could be relatively uncommon, but conversely they might turn out to be far more prevalent than they seem even now. Out of an abundance of caution, I will restrict the discussion to an outline of mechanisms with less reference to burden of disease.
#COVID19 #Coronavirus #Brain
The information provided on this YouTube channel is not intended to replace professional medical advice, diagnosis or treatment. The content presented is for informational purposes only.
Today I explore some of the potential mechanisms of damage to the nervous system by infection with SARS-CoV-2 that have been proposed so far, which can be broadly grouped into two categories - indirect and direct. We will see how parallels can be drawn between COVID-19 and many of our top chronic diseases, and how this might inform how we can combat these neurological effects in the event that we do become infected.
But remember, the only way to ensure we avoid most of these neurological effects remains avoiding the virus altogether.
I will also touch on some nutrients that I think are of particular importance in COVID-19. There is a lot to cover in this video and it has turned out to be quite long even with my best attempts to stick to just the essential stuff, so I have added timestamps to each section below for easy navigation. I have also referenced many of my past videos to back up my points, or this video would have gone on forever! The links to these past videos referenced with timestamps are also provided here if you would like to follow up further:
0:00 Introduction
Diet, brain diseases and motivation for healthy eating:
1:57 Neurological effects observed in previous coronavirus outbreaks
2:22 COVID-19 neurological SYMPTOMS
3:00 Outline of COVID-19 neurological effects
3:46 Indirect effects of the novel coronavirus on the brain:
- 3:58 Blood clotting and disruption to flow
- 4:53 Inflammation, immune system and the 'cytokine storm'
- 5:54 Intestinal microbiome and the gut-brain axis
6:51 Direct and mixed effects of the novel coronavirus on the brain
- 7:00 Retrograde axonal transport
- 7:30 Happy hypoxaemia neural hypothesis: brainstem invasion
- 9:16 Blood-brain barrier
- 9:58 ACE2 receptor
- 10:34 Direct invasion from the blood and neurotoxin ingress
- 11:47 Reduced ACE2 function
- 12:22 Loss of brain blood flow autoregulation
- 12:49 Systemic dysregulation of blood pressure
- 13:27 ACE2-mediated invasion of brain and loss of autonomic function
- 14:12 Invasion and replication in the brain and secondary effects
- 15:34 Post-infectious complications and auto-immunity
16:15 All pathological processes take place on a background of hypoxia
16:49 Mental health effects
18:07 So what do we do about it?
20:25 A case for WFPB diet and specific nutrients
22:54 Modifiable risk factors for severe COVID-19
23:24 Diet and modulation of the immune system
24:25 Intense inflammation, profound immune system priming and predisposition towards brain diseases
25:04 Nutrients that may be of particular importance in COVID-19
- 25:16 Vitamin D
- 26:04 Zinc
- 26:47 Selenium
- 27:46 N-acetylcysteine
My video on zinc:
29:55 The COVID-19 pandemic as an opportunity
31:02 SUMMARY
32:39 A final thought
33:31 Diet and brain health in general
33:54 References
Since this disease has only been with us for around a year and there is no way many of the hypothetical mechanisms of neurological effects can be validated and quantified yet, I have weighted this video towards a qualitative analysis of COVID-19 brain effects. I think it is too early to call how common neurological sequelae are going to be - they could be relatively uncommon, but conversely they might turn out to be far more prevalent than they seem even now. Out of an abundance of caution, I will restrict the discussion to an outline of mechanisms with less reference to burden of disease.
#COVID19 #Coronavirus #Brain
The information provided on this YouTube channel is not intended to replace professional medical advice, diagnosis or treatment. The content presented is for informational purposes only.
0:08:57
Covid and the brain: A neurological health crisis
0:07:38
Here’s what we know about COVID-19’s impact on the brain
0:01:58
How COVID-19 affects the brain
0:02:00
2-Minute Neuroscience: COVID-19 & the Brain
0:07:21
The Science Behind How the Coronavirus Affects the Brain | WSJ
0:02:01
COVID-19 effects on the brain
0:34:18
COVID-19 and the brain...and what you can do about it!
0:28:00
COVID-19 and the Brain
0:01:39
Brain injury & COVID-19 risk: Dr. Robert Cantu
0:26:47
Healthy Minds: How COVID-19 Affects the Brain
0:11:49
COVID-19 Effects on the Brain and Related Cognitive Functions | Cyrus A. Raji, MD, PhD | TEDxStLouis
0:23:23
Headway webinar: Covid-19 and the brain: what we know so far
0:10:25
Covid19 & the Brain
0:01:57
COVID-19 impact on the brain
0:27:23
COVID-19: How the Virus Affects the Brain | Pravin George, MD
0:02:00
Study shows how COVID-19 attacks brain cells
0:03:13
COVID-19's Long Term Effects on the Brain
0:01:31
Doctors looking at the effects of COVID-19 on the brain
0:02:30
Can COVID-19 affect your brain? Doctors say it's possible
0:00:43
Inflammation In The Brain After COVID-19 | Dr. Daniel Amen
0:02:19
How Does Covid-19 Impact the Brain?
0:56:10
COVID-19 and the Brain Webinar | American Brain Foundation
0:04:58
COVID-19 Can Cause Brain Shrinkage, According To Study
0:52:57
RSM COVID-19 Series | Episode 102: Impact on the brain
Комментарии