Linking Cancer Metabolism to Neurodegeneration

Presented By: Navdeep S. Chandel PhD

Speaker Biography: I received a BA in mathematics (1991) followed by a Ph.D. in Cell Physiology (1996) at the University of Chicago with Dr. Paul Schumacker, Then did my post-doctoral fellowship jointly with Dr. Paul Schumacker and Dr. Craig Thompson (1999). I started my lab in 2000 at Northwestern University Feinberg School of Medicine.

Webinar: Linking Cancer Metabolism to Neurodegeneration

Webinar Abstract: The major function of mitochondria in cellular homeostasis has been the generation of ATP through oxidative phosphorylation. However, we have previously demonstrated that mitochondria can serve as signaling organelles by releasing low levels of reactive oxygen species (ROS) that are essential for hypoxic activation of HIF, antigen activation of T cells, cellular differentiation and proliferation of cancer cells.

[iot]

Indeed Prof. this is excellent knowledge dissemination. This is one of the best talk re: metabolic - simply break down. thank you.

[joshuabowman]

There is no talk about the Kinesen and Dynien that move things around and other motor molecules involved with the 5 complexes building them other things

[joshuabowman]

What about AMP of the Mitochondria is not talked about why ?

[Rene-uzeb]

Amazing work. So basically its not the energy loss that causes the degenerative diseases but a few more wheels coming off in the high ROS situation in the krebs cycle.
But cancer seems to be as effected as normal cells with this metabolite imbalance.
I'm going to venture that cancer might be a program to counteract fast dying cells (from ferroptosis or apoptosis/ROS), hence the growth requirement.