Dr. Angela Poff - Exploiting Cancer Metabolism with Ketosis and Hyperbaric Oxygen

Filmed at the Emerging Science of Carbohydrate Restriction and Nutritional Ketosis, Scientific Sessions at The Ohio State University

An impressive body of scientific evidence over the last 15 years documents long term benefits of carbohydrate-restricted, especially ketogenic, diets. We now understand molecular mechanisms and why they work. Popular books and articles now challenge the advice ‘carbohydrates are good and fats are bad.’ Circa mid-19th century urinary ketones were identified in diabetics sealing their toxic label for the next 150 years. Despite work four decades ago showing ketones were highly functional metabolites, they are still misidentified as toxic byproducts of fat metabolism. The vilification of fat by regulatory and popular dogma perpetuates this myth. But the nutrition-metabolic landscape is improving dramatically.

A growing number of researchers have contributed to what is now a critical mass of science that provides compelling clinical evidence that ketogenic diets uniquely benefit weight loss, pre-diabetes, and type-2 diabetes. In the last five years, basic scientists have discovered that b-hydroxybutyrate (BHB), the primary circulating ketone, is a potent signaling molecule that decreases inflammation and oxidative stress. BHB has been suggested to be a longevity metabolite, with strong support from recently published mouse studies showing decreased midlife mortality and extended longevity and healthspan. Although type-2 diabetes is often described as a chronic progressive disease, emerging evidence indicates that sustained nutritional ketosis can reverses the disease. There is growing interest in studying potential therapeutic effects of ketosis on cardiovascular diseases, cancer, and neurodegenerative diseases including Alzheimer’s and Parkinson’s. There are even reasons certain athletes may benefit from nutritional ketosis and ketone supplements ─ debunking the long-standing dogma that high carbohydrate intake is required to perform optimally.

With the support of the well-established Ohio State Food Innovation Center, this conference will bring together the top experts in these fields to share what has been achieved and what remains to be done to advance this exciting field of scientific discovery.

[ecobee]

Congrat for your elegant research. That's what Applied Biochemistry is all about.

[vanilla]

One thing that I don't like is that the survival curves for various therapies arent actually dramatically improved in comparison to control group. Its improved to 60days from 30days. The meaningful result should be many months from 30days

[Hein]

How does inactivating complex 1 of mitochondria affect cancer if they don't have functional mitochondria that produce energy (Thomas Seyfrieds theory)?

[kayeszymanski]

So does a cancer patient need a medical clinic for a hyperbaric oxygen treatment? I know there are non medical places that claim to provide this type of service.

[rickstokes]

If a rise in oxidative stress can decrease cancer cells then why not just use hydrogen peroxide therapies which can naturally lift oxygen levels without the use of ascorbic acid and can be self administered by the patient in the comfort of their home very inexpensively? I’m guessing it’s the ‘self administered’ and ‘very inexpensively’ part that keep that solution from being discussed.

[rajkumark]

Where can I sign up for this kind of studies on me. thanks

[indiegemsthatjam]

Standard rodent chow looks to be ~ 23.9% protein (partial ingred, top to bottom Corn, Soybean, Beet (veg), Fish- & Pork further down) ... curious about Dr Seyfried's 1-2 Punch to cancer cell energy fermentation of limiting glucose and glutamine. Fasting hitting both ... exogenous ketones, hyperbaric oxygen, and fasting could be a potent combo for slowing /killing cancer cells

[SharonJones-fy]

isn't this thomas seyfried's work? or did he just popularize it?

[DarkMoonDroid]

Where do I go to get this?
Experiment on me.
Sign me up!

[carolynschaub]

So how much oral Ascorbate should an Ovarian cancer patient intake?

[maikanoibrahim]

The day I came across Dr IGUDIA YouTube channel was the day I started living a more comfortable life again after using his herbs medication in curing my Diabetes disease