Blood-based detection: EGFR/ KRAS mutations for NSCLC patients using multiplexed droplet digital PCR

Presented By:
Hestia Mellert, PhD

Speaker Biography:
Dr. Mellert is a Senior Director within the Biodesix development group. She has a background in molecular cancer biology and experience leading teams in the development and commercialization of blood-based, and now respiratory based, diagnostic tests under CAP/CLIA and NYS CLEP. Dr. Mellert has played a leading role in the launch and on-market support of the GeneStrat tests which uses ddPCR technology. Most recently she has contributed to the expanded use of this platform at Biodesix to support molecular testing for SARS-CoV-2 infection. She continues to focus her efforts on bringing relevant and actionable genomic and proteomic information into the Clinical Laboratory to support pharmaceutical development programs and physicians. Dr. Mellert received her Ph.D from the University of Pennsylvania and post-doctoral training at the University of Colorado. She has received several honors including the American Cancer Society Post-doctoral fellowship and inaugural Biodesix Invent Our Future award.

Webinar:
Blood-based detection of EGFR and KRAS mutations for NSCLC patients using multiplexed droplet digital PCR

Webinar Abstract:
Mutations in the epidermal growth factor receptor gene (EGFR) and the known Kirsten rat sarcoma viral oncogene (KRAS) are significant drivers in the development of non-small-cell lung cancer (NSCLC). Treatment is typically guided by which mutations are present, and there are several possible mutations that can arise during treatment, so detecting them quickly and reliably is key to helping the patient. With NSCLC, biopsied patient samples tend to be very small, which can hamper many conventional genetic tests. Thus the ideal test in NSCLC is one that can work with minimal inputs, and test for several mutations at the same time. This webcast will present a new liquid biopsy test using multiplexing assays that contained mutant variants. The QX ONE Droplet Digital PCR (ddPCR) System allows for automated operation and advanced multiplexing to detect mutations in EGFR and KRAS using as little as 5 ng of cell-free DNA extracted from plasma.

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