Is FEVER good or bad? What fever does to your body explained

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When was the last time you had a fever? Is fever dangerous or is it actually helpful?

References:

1 Marik, P. E. (2000). Fever in the ICU. Chest, 117(3), 855-869.

2 Sadava, D. E., Hillis, D. M., & Heller, H. C. (2009). Life: the science of biology (Vol. 2). Macmillan.

3 Schmitt, B. D. (1980). Fever phobia: misconceptions of parents about fevers. American journal of diseases of children, 134(2), 176-181.

4 Evans, S. S., Repasky, E. A., & Fisher, D. T. (2015). Fever and the thermal regulation of immunity: the immune system feels the heat. Nature Reviews Immunology, 15(6), 335-349.

5 Kluger, M. J., Ringler, D. H., & Anver, M. R. (1975). Fever and survival. Science, 188(4184), 166-168.

6 Vaughn, L. K., Veale, W. L., & Cooper, K. E. (1980). Antipyresis: its effect on mortality rate of bacterially infected rabbits. Brain research bulletin, 5(1), 69-73.

7 Simone-Finstrom, M., Foo, B., Tarpy, D. R., & Starks, P. T. (2014). Impact of food availability, pathogen exposure, and genetic diversity on thermoregulation in honey bees (Apis mellifera). Journal of insect behavior, 27(4), 527-539.

8 Green, M. H., & Vermeulen, C. W. (1994). Fever and the control of gram-negative bacteria. Research in microbiology, 145(4), 269-272.

9 Robert, V. A., & Casadevall, A. (2009). Vertebrate endothermy restricts most fungi as potential pathogens. The Journal of infectious diseases, 200(10), 1623-1626.

10 Rice, P., Martin, E., He, J. R., Frank, M., DeTolla, L., Hester, L., ... & Hasday, J. D. (2005). Febrile-range hyperthermia augments neutrophil accumulation and enhances lung injury in experimental gram-negative bacterial pneumonia. The Journal of Immunology, 174(6), 3676-3685.

11 Smith, J. B., Knowlton, R. P., & Agarwal, S. S. (1978). Human lymphocyte responses are enhanced by culture at 40 C. The Journal of Immunology, 121(2), 691-694.

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Thanks for reviewing: Julie Kawohl

#fever #explained

0:00 What is fever?
0:58 How does a fever arise?
2:14 Is a fever good or bad?
4:14 Immunological functions of fever